Allopurinol
Therapeutic Group
Anti-Gout PreparationsIndication Dosage
Prophylaxis Of Gout And Of Uric Acid And Calcium Oxalate Renal Stones, Prophylaxis Of Hyperuricaemia Associated With Cancer Chemotherapy:
- Adult: Initially 100-200 Mg Daily To Be Taken Preferably After Food, For Maintenance Adjust Dose According To Plasma Or Urinary Uric Acid Concentration.
In Moderately Severe Conditions:
- Adult: 300-600 Mg Daily In Divided Doses (max. Per Dose 300 Mg)
In Severe Conditions:
- Adult: 700-900 Mg Daily In Divided Doses (max. Per Dose 300 Mg). Dose To Be Taken Preferably After Food.
- Children 1 Month-15 Yr: 10-20 Mg/kg Daily (max 400 Mg Daily), Preferably After Food.
- 15-18 Yr: Initially 100 Mg Daily, Increased According To Response, Max 900 Mg Daily (doses Over 300 Mg Daily Given In Divided Doses); Preferably After Food.
Content
- Tab 100mg /300mg: Allopurinol 100mg /300mg.
Pregnancy
Caution Advised, Use Only If No Safer Alternative
Stability
- Xanthine Oxidase Inhibitor
Contra Indications
- Not A Treatment For Acute Gout But Continue If Attack Develops When Already Receiving Allopurinol, And Treat Attack Separately
Precautions
- Not A Treatment For Acute Gout But Continue If Attack Develops When Already Receiving Allopurinol, And Treat Attack Separately
Lactation
- Caution Advised or Effect Undetermined.
Side Effects
- Gi Disorders
- Rashes (withdraw Therapy; If Occur).
- Rare: Alopecia
- Aplastic Anaemia
- Arthralgia
- Blood Disorders
- Drowsiness
- Eosinophilia Resembling Stevens-johnson Syndrome
- Eosinophilia Resembling Toxic Epidermal Necrolysis
- Exfoliation
- Fever
- Gynaecomastia
- Haemolytic Anaemia
- Headache
- Hepatitis
- Hepatotoxicity
- Hypersensitivity Reactions
- Hypertension
- Leucopenia
- Lymphadenopathy
- Malaise
- Neuropathy
- Paraesthesia
- Renal Impairment
- Taste Disturbances
- Thrombocytopenia
- Vasculitis
- Vertigo
- Visual Disturbances