Capecitabine

Therapeutic Group

Anti-neoplastics

Indication Dosage

Capecitabine is a medication used to treat certain types of cancer, like breast, colon, or rectal cancer. It works by stopping cancer cells from growing and spreading in the body. Your doctor may prescribe it to help fight and control cancer in a way that's easy to take.

III Colon Cancer, Adjuvant Following Surgery (monotherapy): 

  • Adult: 1.25 G/m2 Twice Daily For 14 Days, Subsequent Courses Repeated After A 7-day Interval, Usually For 6 Months, Adjust Dose According To Tolerability 

Stage III Colon Cancer, Adjuvant Following Surgery (Combination Therapy): 

  • Adult: 0.8-1 G/m2 Twice Daily For 14 Days, Subsequent Courses Repeated After A 7-day Interval, Usually For 6 Months, Adjust Dose According To Tolerability 

Metastatic Colorectal Cancer (monotherapy): 

  • Adult: 1.25 G/m2 Twice Daily For 14 Days, Subsequent Courses Repeated After A 7-day Interval, Adjust Dose According To Tolerability 

Metastatic Colorectal Cancer (Combination Therapy): 

  • Adult: 0.8-1 G/m2 Twice Daily For 14 Days, Subsequent Courses Repeated After A 7-day Interval, Adjust Dose According To Tolerability 

Advanced Gastric Cancer (first-line Treatment In Combination With A Platinum-Based Regimen): 

  • Adult: 0.8-1 G/m2 Twice Daily For 14 Days, Subsequent Courses Repeated After A 7-day Interval, Alternatively 625 Mg/m2 Twice Daily Given Continuously, Adjust Dose According To Tolerability 

Locally Advanced Or Metastatic Breast Cancer (second-line Treatment As Monotherapy), Locally Advanced Ormetastatic Breast Cancer (second-line Treatment, In Combination With Docetaxel): 

  • Adult: 1.25 G/m2 Twice Daily For 14 Days, Subsequent Courses Repeated After A 7-day Interval, Adjust Dose According To Tolerability

Content

  • Tab 150mg / 500mg:
  • Cap ecitabine 150mg / 500mg.

Pregnancy

Contraindicated

Stability

  • Antimetabolites

Contra Indications

  • Severe Renal Or Hepatic Impairment, Hypersensitivity To Fluoropyrimidines Or Fluorouracil. Dihydropy-rimidine Dehydrogenase Deficiency, Severe Leucopenia, Neutropenia Or Thrombocytopenia

Precautions

  • Severe Renal Or Hepatic Impairment, Hypersensitivity To Fluoropyrimidines Or Fluorouracil. Dihydropy-rimidine Dehydrogenase Deficiency, Severe Leucopenia, Neutropenia Or Thrombocytopenia

Lactation

  • Contraindicated. Discontinue Breast-feeding.

Side Effects

  • Alopecia
  • bone-marrow Suppression
  • Hyperuricaemia
  • Thrombocytopenia
  • Hyperbilirubinemia
  • Fatigue
  • Anorexia
  • Diarrhoea
  • Fever
  • Eye Disorder
  • Constipation
  • Abdominal Pain
  • Erythema
  • Stimattis
  • Dermatitis
  • Paresthesias
  • Nausea
  • Oral Mucositis
  • Thromboembolism
  • Tumourlysis Syndrome
  • Vomiting

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