Chloramphenicol

Therapeutic Group

Amphenicols

Indication Dosage

Life Threatening Infections Particularly Those Caused By Haemophilus Influenza, Typhoid Fever, Septicaemia, and Meningitis: 

Oral: 

  • Adult: 50 Mg/kg In Divided Doses Every 6 Hours; Children Less Than 2 Weeks: 25 Mg/kg In Divided Doses Every 6 Hours; Over 2 Weeks: Same As Adult. Dose Can Be Doubled For Severe Infections Such As Septicaemia And Meningitis, Providing High Doses Reduced As Soon As Clinically Indicated 

By IV Inj: 

  • Adults & Children: 50-100 Mg/kg/day Given Every 6 Hr. Infants: 25 Mg/kg/day Given Every 6 Hr.

Content

  • Cap 250mg: Chloramphenicol Base 250mg.
  • Susp: Per 5 ml: Chloramphenicol Palmitate Equiv To 125mg Chloramphenicol Base.
  • Inj 1gm: Chloramphenicol (as Sodium Succinate) 1gm; Powder In Vial

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Antimicrobials

Contra Indications

  • Acute Porphyria, History Of Previous Hypersensitivity Or Toxicity With Chloramphenicol, Severe Renal Impairment

Precautions

  • Acute Porphyria, History Of Previous Hypersensitivity Or Toxicity With Chloramphenicol, Severe Renal Impairment

Lactation

  • Contraindicated, Avoid

Side Effects

  • Blood Disorders
  • Depression
  • Diarrhoea
  • Dry Mouth
  • Erythema Multiforme
  • Glossitis
  • Headache
  • Nausea
  • Nocturnal Haemoglobinuria
  • Optic Neuritis
  • Peripheral Neuritis
  • Reversible And Irreversible Aplastic Anaemia (with Reports Of Resulting Leukaemia)
  • stomatitis
  • Urticaria
  • Vomiting