Clarithromycin

Therapeutic Group

Macrolides, Lincosamides And Streptogramins

Indication Dosage

Respiratory-tract Infections, Mild To Moderate Skin And soft-tissue Infections, Otitis Media: 

Oral: 

  • Adult & Children Above 12 Yrs: 250 Mg Twice Daily Usually For 7-14 Days, Increased To 500 Mg Twice Daily, If Required In Severe Infections (e.g. Pneumonia) 
  • Children 1 Month-11 Yrs: Body-weight Up To 8 Kg: 7.5 Mg/kg Twice Daily; Body-weight 8-11 Kg: 62.5 Mg Twice Daily; Body-weight 12-19 Kg: 125 Mg Twice Daily; Body-weight 20-29 Kg: 187.5 Mg Twice Daily; Body-weight 30-40 Kg: 250 Mg Twice Daily 

By IV Infusion: 

  • Adult: 500 Mg Every 12 Hours Maximum Duration 5 Days, Switch To Oral Route When Appropriate, To Beadministered Into A Large Proximal Vein 

Lyme Disease: 

Oral: 

  • Adult & Children Above 12yrs: 500 Mg Twice Daily For 14-21 Days 

Prevention Of Pertussis: 

Oral: 

  • Adult & Children Above 12yrs: 500 Mg Twice Daily For 7 Days 
  • Children 1 Month-11 Yrs: Body-weight Up To 8 Kg: 7.5 Mg/kg; Body-weight 8-11 Kg: 62.5 Mg; Body-weight 12-19 Kg: 125 Mg; Body-weight 20-29 Kg: 187.5 Mg; Body-weight 30-40 Kg: 250 Mg. All Doses Twice Daily For 7 Days 

Helicobacter Pylori Eradication In Combination With A Proton Pump Inhibitor And Amoxicillin: 

Oral: 

  • Adult: 500 Mg Twice Daily. 

In Combination With A Proton Pump Inhibitor And Metronidazole: 

  • Adult: 250 Mg Twice Daily 

Pharyngitis, Tonsillitis, Sinusitis: 

Oral: 

  • Adult: 500 Mg Every 12 Hr For 14 Days. 
  • Children: 6 Months And Older: 7.5 Mg/kg Every 12 hours for 10 Days. 

Prevention & Treatment Of Mycobacterium Avium Complex: 

By IV Infusion: 

  • Adults: 1000 Mg Twice Daily. 
  • Children: 20 Months: 7.5 Mg/kg Every 12 Hr. Max: 500 Mg Every 12 Hr.

Content

  • Drop Per 5 ml: Clarithromycin 125mg.
  • Susp 125mg /250mg: Per 5 ml: Clarithromycin 125mg /250mg; Powder For Reconstitution.
  • Cap /Tab 250mg /500mg: Clarithromycin 250mg /500mg.
  • Inj 500mg: Clarithromycin 500mg.

Pregnancy

Avoid, Particularly In The First Trimester, Unless Potential Benefit Outweighs Risk

Stability

  • Macrolide

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Caution Advised, Avoid

Side Effects

  • Dyspepsia
  • Headache
  • Hyperhidrosis
  • Insomnia
  • Taste Disturbances
  • Anorexia
  • Anxiety
  • Blood Disorders
  • Chest Pain
  • Constipation
  • Dizziness
  • Dry Mouth
  • Flatulence
  • Gastritis
  • Glossitis
  • Hepatic Dysfunction Including Jaundice
  • Leucopenia
  • Malaise
  • Myalgia
  • Stomatitis
  • Tinnitus
  • Tremor
  • Confusion
  • Convulsions
  • Depression
  • Hypoglycaemia
  • Interstitial Nephritis
  • Myopathy
  • Paraesthesia
  • Psychotic Disorders
  • Renal Failure
  • Tongue And Tooth Discoloration

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