Dacarbazine

Therapeutic Group

Anti-neoplastics

Indication Dosage

Indication:

Dacarbazine is a medication used to treat certain types of cancer, like skin cancer called melanoma, and a type of cancer called Hodgkin's lymphoma. It works by stopping the growth of cancer cells in the body.

Dosage:

Metastatic Melanoma And Malignant Lymphomas, Testicular Tumours, Colorectal Cancers, Tumours Of Git, Cns, Soft Tissues, Hodgkin's Disease: 

By IV Infusion, Or By IV Inj: 

  • Adult: 200-500 Mg/m2. Refer to Individual Protocol.

Content

  • Inj 200mg: Dacarbazine 200mg (as Citrate), Mannitol 75mg; Vial.

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Alkylating Agent

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Contraindicated. Discontinue Breast-feeding

Side Effects

  • Alopecia
  • Bone-marrow Suppression
  • Extravasation
  • Hyperuricaemia
  • Myelosuppression
  • Oral Mucositis
  • Severe Nausea
  • Severe Vomiting
  • Tumourlysis Syndrome
  • Vomiting.
  • Rare: Liver Necrosis Due To Hepatic Vein Thrombosis

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