Flucloxacillin

Therapeutic Group

Beta-Lactam Anti-bacterials, Penicillins

Indication Dosage

Infections Due To Beta-lactamase-producing Staphylococci Including Respiratory Tract, Ent, Ut, And Soft Tissue Infections, Gonorrhoea, Dental Abscess, Otitis Externa, Adjunct In Pneumonia, Impetigo And Cellulitis: 

Oral: 

  • Adult: 250-500 Mg 4 Times A Day; 
  • Children 1 Month-1 Year: 62.5-125 Mg 4 Times A Day; 
  • 2-9 Years: 125-250 Mg 4 Times A Day; 
  • 10-17 Years: 250-500 Mg 4 Times A Day 

By IM Inj: 

  • Adult: 250-500 Mg Every 6 Hours 

By Slow IV Inj, Or IV Infusion: 

  • Adult: 0.25-2 G Every 6 Hours 

Endocarditis (in Combination): 

By Slow IV Inj, Oriv Infusion: 

  • Adult: (body-weight Up To 85 Kg): 8 G Daily In 4 Divided Doses; (body-weight 85 Kg And Above): 12 G Daily In6 Divided Doses 

Osteomyelitis: 

By Slow IV Inj, Or IV Infusion: 

  • Adult: Up To 8 G Daily In 3-4 Divided Doses 

Surgical Prophylaxis: 

By Slow IV Inj, Or IV Infusion: 

  • Adult: 1-2 G, To Be Administered Up To 30 Minutes Before The Procedure, Then (by Mouth Or By IM Injection Or By Slow IV Injection Or By IV Infusion) 500 Mg Every 6 Hours If Required For Up To 4 Further Doses In High Riskprocedures 

Staphylococcal Lung Infection In Cystic Fibrosis: 

Oral: 

  • Child: 25 Mg/kg 4 Times A Day (max. Per Dose 1 G), Alternatively 100 Mg/kg Daily In 3 Divided Doses; Maximum 4 G Per Day

Content

  • Cap 250mg /500mg: Flucloxacillin 250mg /500mg.
  • Inj 250mg /500mg: Flucloxacillin 250mg / 500mg; Vial.
  • Syp: Per 5 ml: Flucloxacillin 125mg.

Pregnancy

Use Only If Essential

Stability

  • Penicillinase-resistant Penicillin

Contra Indications

  • History Of Flucloxacillin Associated Jaundice/hepatic Dysfunction, Hypersensitivity To Penicillins, Cephalosporins Or Other Beta-lactams.

Precautions

  • History Of Flucloxacillin Associated Jaundice/hepatic Dysfunction, Hypersensitivity To Penicillins, Cephalosporins Or Other Beta-lactams.

Lactation

  • Caution Advised

Side Effects

  • Hypersensitivity Reactions
  • Gi Disturbane
  • Super Infection
  • hepatic Reactions.
  • Rare: Pseudomembranous Colitis
  • Erythema Multiforme
  • Stevens-johnson Syndrome
  • Toxic Epidermal Necrolysis.