Glipizide And Metformin

Therapeutic Group

Blood Glucose Lowering Drugs, Excluding Insulin

Indication Dosage

Therapy For Type 2 Diabetes Mellitus: 

  • Adults: Initially Tab 2.5-5 Mg Glipizide and Metformin 250/500 Mg Daily, To Be Taken Shortly Before Breakfast Or Lunch, Adjusted According To Response, Dose Higher Than 15 Mg To Be Given In Divided Doses; Maximum Glipizide20 Mg And Metformin Hci 2000 Mgperday. Use Appropriate Strength As Required. 
  • Children: Not Recommended.

Content

  • Tab 2.5 /250mg: Glipizide 2.5mg, Metformin 250mg.
  • Tab 2.5 /500mg: Glipizide 2.5mg, Metformin 500mg.
  • Tab 5 /500mg: Glipizide 5mg, Metformin 500mg.
  • Tab 5 /250mg: Glipizide 5mg, Metformin

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Biguanide
  • Sulphonylurea

Contra Indications

  • Porphyria, Ketoacidosis, Pre-coma And Coma, Severe Renal Or Hepatic Impairment, Concomitant Miconazole Treatment, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Administration Of Iodinated Contrast Materials. Discontinue For 48 Hours Before And After Elective Surgery.

Precautions

  • Porphyria, Ketoacidosis, Pre-coma And Coma, Severe Renal Or Hepatic Impairment, Concomitant Miconazole Treatment, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Administration Of Iodinated Contrast Materials. Discontinue For 48 Hours Before And After Elective Surgery.

Lactation

  • Contraindicated or Not Recommended.

Side Effects

  • Abnormal Liver Function Tests
  • Hepatitis
  • Jaundice
  • Blood Dyscrasias
  • Transient Visual Disturbances
  • Skin Reactions
  • Reduced B12 Absorptions
  • Gi Upset
  • Taste Disturbance
  • Rarely Lactic Aci-dosis.

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