Imipramine

Therapeutic Group

Anti-depressants

Indication Dosage

Indication:

Imipramine is a medication that is used to treat conditions like depression. It helps improve mood and can be especially helpful when a person feels very sad or lacks energy for an extended period. Imipramine can also be prescribed for people with bedwetting issues, helping them to control their bladder during sleep.

Dosage:

Depressive Illness: 

  • Adult: Initially Up To 75 Mg Daily In Divided Doses, Then Increased To 150-200 Mg Daily, Up To 150mg May Be Given As A Single Dose At Bedtime, Dose To Be Increased Gradually; Up To 300 Mg In Hospital Patients 
  • Elderly: Initially 10 Mg Daily, Increased To 30-50 Mg Daily, Dose To Be Increased Gradually 

Nocturnal Enuresis: 

  • Child 6-7 Years: 25 Mg Once Daily At Bedtime, Initial Period Of Treatment (including Gradual Withdrawal) 3 Months; Full Physical Examination Before Further Course; 
  • 8-10 Years: 25-50 Mg Once Daily At Bedtime, Initial Period Of Treatment (including Gradual Withdrawal) 3 Months-full Physical Examination Before Further Course; 
  • 11-17 Years: 50-75 Mg Once Daily At Bedtime, Initial Period Of Treatment (including Gradual Withdrawal) 3 Months-full Physical Examination Before Further Course

Content

  • Tab 10mg /25mg /75mg: Imipramine Hci 10mg /25mg /75mg.

Pregnancy

Avoid Unless Potential Benefit Outweighs Risk

Stability

  • Tricyclic Antidepressant (tcad)

Contra Indications

  • Acute Porphyrias, Arrhythmia, Immediate Recovery Period After Myocardial Infarction, During The Manic Phase Of Bipolar Disorder, Heart Block

Precautions

  • Acute Porphyrias, Arrhythmia, Immediate Recovery Period After Myocardial Infarction, During The Manic Phase Of Bipolar Disorder, Heart Block

Lactation

  • Contraindicated, Avoid

Side Effects

  • Agitation
  • Alopecia
  • Anorexia
  • Anxiety
  • Arrhythmia
  • Blurred Vision
  • Fatigue
  • Flushing
  • Headache
  • Palpitation
  • Restlessness
  • Chills
  • Confusion
  • Convulsions
  • Delusions
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Dysarthria
  • Ecg Changes
  • Galactorrhoea
  • Gynaecomastia
  • Haematologial Reactions
  • Hallucinations
  • Headache
  • Heart Block
  • Hepatic Reactions
  • Hypomania
  • Hyponatraemia
  • Increased Appetite
  • Insomnia
  • Irritability
  • Mania
  • Movement Disorders
  • Myalgia
  • Nausea
  • Paraesthesia
  • Photosensitivity
  • Postural Hypotension
  • Pruritus
  • rash
  • Sexual Dysfunction
  • Sleep Disturbances
  • Sudden Death
  • Suicidal Behavior
  • Sweating
  • Tachycardia
  • Taste Disturbance
  • Tinnitus
  • Tremor
  • Urinary Retention
  • Urticaria
  • Vomiting
  • Weight Changes.
  • Rare: Extrapyramidal Symptoms
  • Paralytic Ileus