Isosorbide Dinitrate

Therapeutic Group

Cardiac Therapy

Indication Dosage

Isosorbide dinitrate is a medication primarily prescribed to treat and prevent chest pain or angina in individuals with coronary artery disease. It works by relaxing and dilating the blood vessels, which helps to increase blood flow and oxygen supply to the heart muscle. This medication is used to alleviate the discomfort associated with angina attacks and reduce the frequency and severity of these episodes, ultimately improving the overall quality of life for individuals with this condition.

Prophylaxis And Treatment Of Angina: 

  • Oral: Adult: 30-120 Mg Daily In Divided Doses 
  • By IV Infusion: Adult: 2-10 Mg/hour, Increased If Necessary Up To20 Mg/hour 

Left Ventricular Failure, Congestive Heart Failure: 

  • Oral: Adult: 40-160 Mg Daily In Divided Doses, Increased If Necessary Up To 240 Mg Daily In Divided Doses 
  • By IV Infusion: Adult: Initially 2-10 Mg/hour, Increased If Necessary Upto 20 Mg/hour 

Prophylaxis Of Angina: 

  • Oral: Adult: 40 Mg Daily In 1-2 Divided Doses, Increased If Necessary To 60-80 Mg Daily In 2-3 Divided Doses

Content

  • Cap 40mg /20mg: Isosorbide Dinitrate 40mg /20mg; Sustained-Release Cap.
  • Inj: Iv Infusion: Per ml: Isosorbide Dinitrate 1mg; 10 ml (10mg) Amp.
  • Tab 10mg /20mg /40mg: Isosorbide Dinitrate 10mg /20mg /40mg

Pregnancy

Caution Advised, Avoid Unless Potential Benefit Outweighs Risk.

Stability

  • Nitrate

Contra Indications

  • Hypersensitivity To Nitrates; Hypotensive Conditions And Hypovolaemia; Hypertrophic Cardiomyopathy; Aortic Stenosis; Cardiac Tamponade; Constrictive Pericarditis; Mitral Stenosis; Toxic Pulmonary Oedema; Head Trauma; Cerebral Haemorrhage; Cerebrovascular Disease; Marked Anaemia.

Precautions

  • Hypersensitivity To Nitrates; Hypotensive Conditions And Hypovolaemia; Hypertrophic Cardiomyopathy; Aortic Stenosis; Cardiac Tamponade; Constrictive Pericarditis; Mitral Stenosis; Toxic Pulmonary Oedema; Head Trauma; Cerebral Haemorrhage; Cerebrovascular Disease; Marked Anaemia.

Lactation

  • Caution Advised

Side Effects

  • Postural Hypotension
  • Tachycardia
  • Paradoxical Bradycardia
  • Throbbing Headache
  • Dizziness
  • Nausea
  • Vomiting
  • Heartburn
  • Flushing
  • Syncope
  • Temporary Hypoxaemia
  • Rash.
  • Rare: Angle-closure Glaucoma. Injection Specific Side-effects Include Severe Hypotension
  • Diaphoresis
  • Apprehension
  • Restlessness
  • Muscle Twitching
  • Retrosternal Discomfort
  • Palpitation
  • Abdominal Pain
  • Prolonged Administration Has Been Associated With Methaemoglobinaemia.

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