Linezolid

Therapeutic Group

Other Anti-Bacterial

Indication Dosage

Pneumonia (when Other Antibacterials Cannot Be Used), Complicated Skin, And Soft-tissue Infections Caused By Gram-positive Bacteria, When Other Antibacterials Cannot Be Used: 

Oral: 

  • Adult & Children Above 12 Yrs: 600 Mg Every 12 Hours Usually For 10-14 Days; Maximum Duration Of Treatment 28 Days; 
  • Children Birth-11 Yr: 10 Mg/kg Every 8 Hr For 10-14 Days 

By IV Infusion: 

  • Adult: 600 Mg Every 12 Hours 

Lower Respiratory Infection: 

Oral: 

  • Adults & Children Above 12 Yr: 600 Mg Every 12 Hr For 10-14 Days 
  • Children Birth-11 Yr: 10 Mg/kg Orally Every 8 Hr.

Content

  • Tab 400mg /600mg: Linezolid 400mg /600mg. Inf Per ml: Linezolid 2mg, 100 ml (200mg), 200 ml (400mg), 300 ml (600mg).
  • Susp 100mg: Per 5 ml: Linezolid 100mg.

Pregnancy

Caution Advised, Use Only If Potential Benefit Outweighs Risk

Stability

  • Antibiotic: Oxazolidinone

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Caution Advised, Avoid

Side Effects

  • Abdominal Pain
  • Diarrhoea
  • Eosinophilia
  • Headache
  • Nausea
  • Taste Disturbances
  • Vomiting
  • Blurred Vision
  • Constipation
  • Diaphoresis
  • Dizziness
  • Dry Mouth
  • Dyspepsia
  • Electrolyte Disturbances
  • Fatigue
  • Fever
  • Gastritis
  • Glossitis
  • Hypertension
  • Hypoaesthesia
  • Insomnia
  • Leucopenia
  • Pancreatitis
  • Paraesthesia
  • Polyuria
  • Pruritus
  • Rash
  • Stomatitis
  • Thirst
  • Thrombocytopenia
  • Tinnitus
  • Tongue & Tooth Discoloration
  • Anaemia
  • Antibiotic-associated Colitis
  • Convulsions
  • Hyponatraemia
  • Lactic Acidosis
  • Optic Neuropathy (on Prolonged Therapy)
  • Pancytopenia
  • Peripheral Neuropathy (on Prolonged Therapy)
  • Stevens-johnson Syndrome
  • Toxic Epidermal Necrolysis.
  • Rare: Renal Failure
  • Tachycardia
  • Transient Ischaemic Attacks

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