Losartan And Hydrochlorothiazide

Therapeutic Group

Angiotensin-ii Antagonists, Combinations

Indication Dosage

Hypertension Not Adequately Controlled With Losartan Alone: 

  • Adults: Initially 1 Tab Daily, Increased To Max 100 Mg Losartan Daily If Necessary. 
  • Children: Not Recommended.

Content

  • Tab 50 /12.5mg: Losartan Potassium 50mg, Hydrochlorothiazide 12.5mg.
  • Tab 100 /12zmg: Losartan Potassium 100mg, Hydrochlorothiazide 12.5mg.
  • Tab 100 /25mg: Losartan Potassium 100mg, Hydrochlorothiazide 25mg.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Angiotensin II Antagonist
  • Thiazide Diuretic

Contra Indications

  • Hepatic Impairment, Anuria, Moderate To Severe Renal Impairment, Dialysis, Intravascular Volume Depletion.

Precautions

  • Hepatic Impairment, Anuria, Moderate To Severe Renal Impairment, Dialysis, Intravascular Volume Depletion.

Lactation

  • Not Recommended.

Side Effects

  • Hyperkalaemia
  • Angioedema
  • Symptomatic Hypotension Including Dizziness Particularly In Patients With Intravascular Volume Depletion
  • E.g. Those Taking High-dose Diuretics
  • Arthralgia
  • Rhinitis
  • Flatulence
  • Orthostatic Effects
  • Diarrhoea
  • Liver Function Abnormalities
  • Myalgia
  • Hypertriglyceridaemia
  • Migraine
  • Urticaria
  • Pruritus
  • Rash.
  • Rare: Anaphylactic Reactions
  • Angioedema
  • Vasculitis
  • Hepatitis
  • Cough
  • Anaemia

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