Penicillamine

Therapeutic Group

All Other Therapeutic Products, Anti-dotes

Indication Dosage

Cystinuria: 

  • Adults: Treatment: 1-3 Gm Daily In Divided Doses Before Food, Adjusted To Maintain Urinary Cystine Below 200 Mg/l; Prophylaxis: Dose Adjusted To Maintain Urinary Cystine Below 300 Mg/l, 0.5-1gm At Bedtime. 
  • Elderly And Children: Use a Minimum Dose To Maintain Urinary Cystine Below 200 Mg/l. 

Wilson's Disease: 

  • Adult: 1.5- 2 Gm Daily In Divided Doses Before Food; Max 2 Gm Daily For 1 Yr. Maintenance. 0.75-1 Gm Daily 
  • Elderly: 20 Mg/kg Daily In Divided Doses, Minimum 500 Mg Daily. 
  • Children: Up To 20 Mg/kg Daily In Divided Doses; Minimum 500 Mg Daily. 

Lead Poisoning: 

See Product Literature 

Autoimmune Hepatitis (used Rarely): 

  • Adult: Initially 500 Mg Daily In Divided Doses, To Be increased Slowly Over 3 Months; Maintenance 1.25 G daily

Content

  • Tab 250mg: Penicillamine 250mg.

Pregnancy

Contraindicated, Avoid

Stability

  • Chelating Agent

Contra Indications

  • Moderate To Severe Renal Impairment, Lupus Erythematosus, Agranulocytosis, Aplastic Anaemia Or Thrombocytopenia Due To Penicillamine.

Precautions

  • Moderate To Severe Renal Impairment, Lupus Erythematosus, Agranulocytosis, Aplastic Anaemia Or Thrombocytopenia Due To Penicillamine.

Lactation

  • Caution Advised

Side Effects

  • Anorexia
  • Fever
  • Nausea
  • Proteinuria
  • Rash
  • Thrombocytopenia (withdraw)
  • Dysgeusia
  • Haematuria (withdraw)
  • Leucopenia (withdraw)
  • Delayed Rash
  • Breast Enlargement
  • Aplastic Anaemia
  • Blood Disorders
  • Bronchiolitis
  • Cholestatic Jaundice
  • Dermatomyositis
  • Glomerulonephritis
  • Goodpasture's Syndrome

Available Brands