Piperacillin And Tazobactam
Therapeutic Group
Beta-Lactam Anti-bacterials, PenicillinsIndication Dosage
Pneumonia, Septicaemia, Complicated Infections Of Urinary-tract, Respiratory Tract, Abdominal, Skin & Soft-tissues:
By Slow IV Inj Or IV Infusion:
- Adult: 4.5 G Every 8 Hours; Increased If Necessary To 4.5 G Every 6 Hours, Increased Frequency May Be Used for Severe Infections
Infections In Neutropenic Patients:
By Slow IV Inj Or IV Infusion:
- Adult: 4.5 G Every 6 Hours with Aminoglycosides.
- Children: 90 Mg/kg 6 Hourly With Aminoglycosides; Max 4.5 Gm Six Hourly.
Appendicitis:
By Slow IV Inj Or IV Infusion:
- Adult: 4.5 G Every 8 Hours; Increased If Necessary To4.5 G Every 6 Hours
- Children 2-12 Yr: 112.5 Mg/kg Eight Hourly; Max 4.5 Gm Eight Hourly.
Content
- Inj 2.25gm: PiPeracillin (as Sodium) 2gm, Tazo-bactam (as Sodium) 250mg; Powder In Vials.
- Inj 4.5gm: PiPeracillin (as Sodium) 4gm, Tazobactam (as Sodium) 500mg; Powder In Vials.
Pregnancy
Caution Advised, Avoid
Stability
- Beta-lactamase Inhibitor
- Broad-spectrum Penicillin
Contra Indications
- Hypersensitivity To Penicillins, Cephalosporins Or Other Beta-lactams.
Precautions
- Hypersensitivity To Penicillins, Cephalosporins Or Other Beta-lactams.
Lactation
- Caution Advised
Side Effects
- Gi Disturbances
- Nausea
- Vomiting
- Constipation
- Dyspepsia
- Headache
- Hypotension
- Injection-site Reactions
- Insomnia
- Jaundice
- Stomatitis.
- Rare: Eosinophilia
- Hepatitis
- Hypoglycaemia
- Hypokalaemia
- Pancytopenia
- Steven-johnson Syndrome
- Toxic Epidermal Necrolysis
- Allergic Reactions