Propranolol

Therapeutic Group

Beta Blocking Agent

Indication Dosage

Thyrotoxicosis (adjunct): 

  • Oral - Adult: 10-40 Mg 3-4 Times A Day 

Thyrotoxic Crisis: 

By IV Inj: 

  • Adult: 1 Mg, To Be Given Over 1 Minute, Dose May Be Repeated If Necessary At Intervals Of 2 Minutes, Total Dose Is 5mg In Anaesthesia; Maximum 10 Mg Per Course 

Hypertension: 

  • Oral - Adult: Initially 80 Mg Twice Daily, Dose Should Be Increased At Weekly Intervals As Required; Maintenance 160-320 Mg Daily 

Prophylaxis Of Variceal Bleeding In Portal Hypertension: 

  • Oral - Adult: Initially 40 Mg Twice Daily, Then Increased To 80 Mg Twice Daily (max. Per Dose 160 Mg Twice Daily), Dose To Be Adjusted According To Heart Rate 

Phaeochromocytoma (only With An Alpha-blocker) In Preparation For Surgery: 

  • Oral - Adult: 60 Mg Daily For 3 Days Before Surgery 

Phaeochromocytoma (only With An Alpha-blocker) In Patients Unsuitable For Surgery: 

  • Oral - Adult: 30 Mg Daily 

Angina: 

  • Adult: Initially 40 Mg 2-3 Times A Day; Maintenance 120-240 Mg Daily 

Hypertrophic Cardiomyopathy, Anxiety Tachycardia: 

  • Adult: 10-40 Mg 3-4 Times A Day 

Anxiety With Symptoms Such As Palpitation, Sweating Andtremor: 

  • Adult: 40 Mg Once Daily, Then Increased If Necessary To 40 Mg 3 Times A Day 

Prophylaxis After Myocardial Infarction: 

  • Adult: Initially 40 Mg 4 Times A Day For 2-3 Days, Then 80 Mg Twice Daily, Start Treatment 5 To 21 Days After Infarction 

Essential Tremor: 

  • Adult: Initially 40 Mg 2-3 Times A Day; Maintenance 80-160 Mg Daily 

Migraine Prophylaxis: 

  • Adult: 80-240 Mg Daily In Divided Doses 

Arrhythmias: 

  • Oral - Adult: 10-40 Mg 3-4 Times A Day 

By IV Inj: 

  • Adult: 1 Mg, To Be Given Over 1 Minute, Dose May Be Repeated If Necessary At Intervals Of 2 Minutes, Maximum 10 Mg Per Course (5mg In Anaesthesia) 
  • Children: Not Recommended.

Content

  • Tab 10mg /40mg /80mg /160mg: Propranolol (hci) 10mg /40mg /80mg /160mg,
  • Inj: Per ml: Propranolol (hci) 1mg; 10 ml Amp.

Pregnancy

Avoid, Risk Cannot Be Ruled Out.

Stability

  • Non-cardio Selective Beta-blocker

Contra Indications

  • Acute Or Decompensated Heart Failure Requiring Intravenous Inotropes, 2nd Or 3rd Degree Av Block (without Pacemaker), Severe Bradycardia, Sick Sinus Syndrome, Uncontrolled Heart Failure, Cardiogenic Shock, Severe Peripheral Arterial Disease, Hypotension, Metabolic Acidosis, Untreated Pheochromocytoma, Severe Asthma Or Copd.

Precautions

  • Acute Or Decompensated Heart Failure Requiring Intravenous Inotropes, 2nd Or 3rd Degree Av Block (without Pacemaker), Severe Bradycardia, Sick Sinus Syndrome, Uncontrolled Heart Failure, Cardiogenic Shock, Severe Peripheral Arterial Disease, Hypotension, Metabolic Acidosis, Untreated Pheochromocytoma, Severe Asthma Or Copd.

Lactation

  • Caution Advised or Effect Undetermined,

Side Effects

  • Cardiovascular Effects Including Bradycardia
  • Postural Hypotension
  • Depression
  • Oedema
  • Increased Av Block
  • Cardiac Arrhythmias
  • Raynaud's Phenomenon
  • Cold Extremities
  • Sexual Dysfunction
  • Gi Upset
  • Sleep And Cns Disturbances
  • Skin Reactions
  • Fatigue
  • Paraesthesia
  • Peripheral Neuropathy
  • Arthralgia
  • Myopathy
  • Altered Blood Sugar Haematology And Lipid Levels. Withdraw If Unexplained Dry Eyes Or Rash. Rarely
  • Heart Failure
  • Dyspnea
  • Bronchospasm

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