Rifampicin And Isoniazid
Therapeutic Group
Anti-mycobacterials (Anti-tuberculosis)Indication Dosage
Treatment Of Tuberculosis (continuation Phase):
- Adult (body-weight Up To 50 Kg): 450/300 Mg Daily For 4 Months (continuation Phase After 2-month Initial Phase), Preferably Taken Before Breakfast
- Adult (body-weight 50 Kg And Above): 600/300 Mg Daily for 4 Months (continuation Phase After 2-month Initial Phase), Preferably Taken before Breakfast.
- Children: Up To 20 Mg/kg Daily Calculated As Rifampicin To Be Given As A Single Dose.
Content
- Susp /Syp 100 /50mg: Per 5 ml: Rifampicin 100mg, Isoniazid 50mg.
- Powder: Isoniazid 30mg, Rifampicin 60mg; Sachet.
- Cap /Tab 150 /100mg: Rifampicin 150mg, Isoniazid 100mg.
- Cap /Tab 300 /150mg: Rifampicin 300mg, Isoniazid 150mg
Pregnancy
Caution Advised, Use Only If Potential Benefit Outweighs Risk
Stability
- Isonicotinio Acid Derivative
- Rifamycin
Contra Indications
- Previous Hypersensitivity To Any Rifamycin, Patients With Previous Isoniazid Associated Hepatic Injury Or Other Severe Adverse Reactions With Isoniazid.
Precautions
- Previous Hypersensitivity To Any Rifamycin, Patients With Previous Isoniazid Associated Hepatic Injury Or Other Severe Adverse Reactions With Isoniazid.
Lactation
- Caution Advised
Side Effects
- Anaphylactoid Reactions
- Heartburn
- Epigastric Dis-tress
- Anorexia
- Nausea
- Vomiting
- Diarrhoea
- Sore Mouth
- Rash
- Pruritus
- Urticaria
- Eosinophilia
- Thrombocytopenia
- Muscular Weakness
- Pain In Extremities
- Visual Disturbances
- Haernoglobinuria
- Hematuria
- Menstrual Disturbances
- Peripheral Neuropathy
- Elevated Sgot
- Sgpt
- Sgopt
- Agranulocytosis
- Fever
- Skin Eruptions
- Pyridoxine Deficiency.