Tamoxifen

Therapeutic Group

Endocrine Hormone Therapy

Indication Dosage

Tamoxifen is a medication primarily indicated for the treatment of breast cancer. It is commonly prescribed to both pre-and post-menopausal women with hormone receptor-positive breast cancer to help prevent the recurrence of the disease, reduce the risk of new cancer formation in the contralateral breast, and as adjuvant therapy following surgical interventions

Pre- And Peri-menopausal Women With Oestrogen Receptor Positive Breast Cancer Not Previously Treated With Tamoxifen: 

  • Adult: 20 Mg Daily Increasing To 40 Mg Daily If Necessary 

Anovulatory Infertility: 

  • Adult: Initially 20 Mg Daily On Days 2, 3, 4 And 5 Of Cycle, If Necessary Increased To 40 Mg Then 80 Mg For Subsequent Courses; If Cycles Irregular, Start Initial Course On Any Day, With Subsequent Course Starting 45 Days Later Or On Day 2 Of Cycle If Menstruation Occurs

Content

  • Tab 10mg /20mg: Tamoxifen (as Citrate) 10mg /20mg.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Anti-oestrogen

Contra Indications

  • Treatment Of Infertility Contraindicated If Personal Or Family History Of Idiopathic Venous Thromboembolism Or Genetic Predisposition To Thromboembolism

Precautions

  • Treatment Of Infertility Contraindicated If Personal Or Family History Of Idiopathic Venous Thromboembolism Or Genetic Predisposition To Thromboembolism

Lactation

  • Contraindicated. Discontinue Breast-feeding

Side Effects

  • Alopecia
  • Anaemia
  • Cataracts
  • Corneal Changes
  • Decreased Platelet Counts
  • Endometrial Changes
  • Gi Disturbances
  • Hot Flushes
  • Thromboembolic Events
  • Leucopenia
  • Liver Enzyme Changes
  • Oedema
  • Pancreatitis
  • Pruritus Vulvae
  • Retinopathy
  • Suppression Of Menstruation
  • Thrombocytopenia
  • Tumour Flare
  • Uterine Fibroids
  • Vaginal Bleeding
  • Visual Disturbances.
  • Rare: Angioedema
  • Bullous Pemphigoid
  • Cholestasis
  • Fatty Liver
  • Hepatitis
  • Hypertriglyceridaemia
  • Interstitial Pneumonitis
  • Neutropenia
  • Stevens-johnson Syndrome (discontinue)