Tamoxifen
Therapeutic Group
Endocrine Hormone TherapyIndication Dosage
Tamoxifen is a medication primarily indicated for the treatment of breast cancer. It is commonly prescribed to both pre-and post-menopausal women with hormone receptor-positive breast cancer to help prevent the recurrence of the disease, reduce the risk of new cancer formation in the contralateral breast, and as adjuvant therapy following surgical interventions
Pre- And Peri-menopausal Women With Oestrogen Receptor Positive Breast Cancer Not Previously Treated With Tamoxifen:
- Adult: 20 Mg Daily Increasing To 40 Mg Daily If Necessary
Anovulatory Infertility:
- Adult: Initially 20 Mg Daily On Days 2, 3, 4 And 5 Of Cycle, If Necessary Increased To 40 Mg Then 80 Mg For Subsequent Courses; If Cycles Irregular, Start Initial Course On Any Day, With Subsequent Course Starting 45 Days Later Or On Day 2 Of Cycle If Menstruation Occurs
Content
- Tab 10mg /20mg: Tamoxifen (as Citrate) 10mg /20mg.
Pregnancy
Contraindicated In Pregnancy.
Stability
- Anti-oestrogen
Contra Indications
- Treatment Of Infertility Contraindicated If Personal Or Family History Of Idiopathic Venous Thromboembolism Or Genetic Predisposition To Thromboembolism
Precautions
- Treatment Of Infertility Contraindicated If Personal Or Family History Of Idiopathic Venous Thromboembolism Or Genetic Predisposition To Thromboembolism
Lactation
- Contraindicated. Discontinue Breast-feeding
Side Effects
- Alopecia
- Anaemia
- Cataracts
- Corneal Changes
- Decreased Platelet Counts
- Endometrial Changes
- Gi Disturbances
- Hot Flushes
- Thromboembolic Events
- Leucopenia
- Liver Enzyme Changes
- Oedema
- Pancreatitis
- Pruritus Vulvae
- Retinopathy
- Suppression Of Menstruation
- Thrombocytopenia
- Tumour Flare
- Uterine Fibroids
- Vaginal Bleeding
- Visual Disturbances.
- Rare: Angioedema
- Bullous Pemphigoid
- Cholestasis
- Fatty Liver
- Hepatitis
- Hypertriglyceridaemia
- Interstitial Pneumonitis
- Neutropenia
- Stevens-johnson Syndrome (discontinue)