Tapentadol
Therapeutic Group
OpioidsIndication Dosage
Moderate To Severe Acute Pain Which Can Be Managed Only With Opioid Analgesics:
- Adult: Initially 50 Mg Every 4-6 Hours, Adjusted According To Response, Maximum 700 Mg In The First 24 Hours, An Additional Dose Of 50 Mg May Be Taken 1 Hour After The Initial Dose, If Pain Control is Not Achieved; Maximum of 600 Mg Per Day
Severe Chronic Pain:
- Adult: Initially 50 Mg Every 12 Hours, Adjusted According To Response; Maximum 500 Mg Per Day
Content
- Tab 75mg: Tapentadol 75mg
Pregnancy
Risk Of Respiratory Depression And Withdrawal Symptoms In The Neonate, Risk Of Gastric Stasis And Inhalation Pneumonia In The Mother If Opioid Analgesics Are Used During Labour And Delivery
Stability
- Analgesic
- Opioids
Contra Indications
- Acute Respiratory Depression, Comatose Patients, Head Injury And Raised Intracranial Pressure (opioid Analgesics Interfere With Pupillary Responses Vital For Neurological Assessment), Risk Of Paralytic Ileus, Severe Renal Impairment; Avoid Use Or Reduce Dose; Opioid Effects Increased, Prolonged And Increased Cerebral Sensitivity Occurs.
Precautions
- Acute Respiratory Depression, Comatose Patients, Head Injury And Raised Intracranial Pressure (opioid Analgesics Interfere With Pupillary Responses Vital For Neurological Assessment), Risk Of Paralytic Ileus, Severe Renal Impairment; Avoid Use Or Reduce Dose; Opioid Effects Increased, Prolonged And Increased Cerebral Sensitivity Occurs.
Lactation
- Not Recommended
Side Effects
- Abdominal Pain
- Biliary Spasm
- Bradycardia
- Confusion
- Constipation
- Drug Dependence
- Difficulty With Micturition
- Dizziness
- Drowsiness
- Dry Mouth
- Dysphoria
- Euphoria
- Flushing
- Hallucinations
- Headache
- Miosis
- Nausea
- Oedema
- Palpitation
- Postural Hypotension
- Pruritus
- Rash
- RespiratoryDepression
- Sexual Dysfunction
- Sleep Disturbances
- Sweating
- Tachycardia
- Ureteric Spasm
- Urinary Retention
- Urticaria
- Vertigo
- Visual Disturbances
- Vomiting
- Agitation
- Anorexia
- Anxiety
- Asthenia
- Diarrhoea
- Dyspepsia
- Dyspnea
- Fatigue
- Paraesthesia
- Vasodilatation.
- Rare: Angina
- Diverticulitis
- Dysphagia
- Impaired Concentration
- Paralytic Ileus
- Psychosis