Teicoplanin

Therapeutic Group

Glycopeptide Anti-bacterials

Indication Dosage

Serious Infections Caused By Gram-positive Bacteria Such As Complicated Skin And Soft-tissue Infections, Pneumonia: 

By IV Inj, By IV Infusion, or By IM Inj: 

  • Adult (body weight Up To 70 Kg): Initially 400 Mg Every12 Hours For 3 Doses, Followed By 400 Mg Once Daily; (body weight 70 Kg And Above): Initially 6 Mg/kg every 12 Hours For 3 Doses, Then 6 Mg/kg Once Daily 
  • Children: Neonates: 16 Mg/kg Body Weight As A Single Dose By IV Infusion Over 30 Min On First Day, Then 8 Mg/kg Body Weight As Single Daily Dose; Over 2 Months: Moderate Infections: 10 Mg/kg Body Weight By IV Injection Every 12 Hr For First Three Doses, Then 6 Mg/kg By Iv Or IM Injection As A Single Dose Daily; Severe Infections: 10 Mg/kg By Iv Or IM Injection As A Single Dose Daily. 

Streptococcal Or Enterococcal Endocarditis (in combination With Another Antibacterial): 

By IV Inj, Or By IV Infusion: 

  • Adult: Initially 10 Mg/kg Every 12 Hours For 3-5 Doses, Then 10 Mg/kg Once Daily, Subsequent Doses Can Be Given By Intramuscular Injection 

Bone And Joint Infections: 

By IV Inj, Or By IV Infusion: 

  • Adult: Initially 12 Mg/kg Every 12 Hours For 3-5 Doses, Then 12 Mg/kg Once Daily Subsequent Doses Can Begiven By Intramuscular Injection, Increased Risk Of Fever and Rash With Doses Of 12 Mg/kg 

Surgical Prophylaxis: 

By IV Injection: 

  • Adult: 400 Mg, To Be Administered Up To 30 Minutes Before The Procedure 

Surgical Prophylaxis In Open Fractures: 

By IV Infusion: 

  • Adult: 800 Mg, To Be Administered Up To 30 Minutes Before Skeletal Stabilisation And Definitive Soft-tissue closure 

Peritonitis Associated With Peritoneal Dialysis: 

By Intraperitoneal Administration: 

  • Adult: (consult Product Literature)

Content

  • Inj 200mg /400mg: Teicoplanin 200mg /400mg; Powder In Vials.

Pregnancy

Caution Advised, Use Only If Potential Benefit Outweighs Risk.

Stability

  • Antibiotic, Glycopeptide

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Caution Advised

Side Effects

  • Pruritus
  • Rash
  • Bronchospasm
  • Diarrhoea
  • Dizziness
  • Eosinophilia
  • Fever
  • Headache
  • Leucopenia
  • Mild Hearingloss
  • Nausea
  • Thrombocytopenia
  • Thrombophlebitis
  • Tinnitus
  • Vestibular Disorders
  • Vomiting
  • Exfoliative Dermatitis
  • Nephrotoxicity
  • Renal Failure
  • Stevens-johnson Syndrome
  • Toxic Epidermal Necrolysis