Terbutaline

Therapeutic Group

Drugs For Obstructive Airway Diseases, Systemic

Indication Dosage

Asthma, Conditions Associated With Reversible airways Obstruction: 

Oral: 

  • Adult: Initially 2.5 Mg Tab 3 Times A Day For 1-2 Weeks, Then increased To Up To 5 Mg 3 Times A Day 
  • Children 7-15 Yr: 2.5 Mg Tab 2 Or 3 Times Daily 
  • Children 3-7 Yr: 2.5-5 Ml Syrup 8 Hourly; 
  • Children 7-15 Yr: 5-10 Ml Syrup 8 Hourly 

By Sc Inj, Or By Slow IV Inj:

  • Adult: 250-500 Mcg Up To 4 Times A Day, Use In Severe Cases Where Oral Therapy Is Inappropriate Or Ineffective 

By Cont. Iv Infusion: 

  • Adult: 90-300 Mcg/hour For 8-10 Hours, To Beadministered As A Solution Containing 3-5 Mcg/ml, High Doses Require Close monitoring, Use In Severe Cases Where Oral Therapy Is Inappropriate Or Ineffective 

Acute Asthma: 

Oral: 

  • Adults: 2.5 Mg-5 Mg Tab 2 Or 3 Times Daily Or 10-15 Ml Syrup 8 Hourly 
  • Children 7-15 Yr: 2.5 Mg Tab 2 Or 3 Times Daily 
  • Children 3-7 Yr: 2.5-5 Ml Syrup 8 Hourly; 
  • 7-15 Yr: 5-10 Ml Syrup 8 Hourly 

By Sc Inj, Or By Slow IV Inj:

  • Children 2-14 Yrs: 10 Mcg/kg Up To 4 Times A Day(max. Per Dose 300 Mcg); 
  • 15-17 Years: 250-500 Micrograms Up To 4 Times Aday, Use In Severe Cases Where Oral Therapy Is Inappropriate Or Ineffective 

By Cont. Iv Infusion: 

  • Children: Loading Dose 2-4 Mcg/kg, Then1-10 Mcg/kg/hour, Dose To Be Adjusted According To Response And Heart Rate, Close Monitoring is Required For Doses Above 10 Mcg/kg/hour, Use In Severe Cases Where Oral Therapy Is Inappropriate Or Uneffective 

Exacerbation Of Reversible Airways Obstruction (including Nocturnal Asthma), Prevention Of Exercise-induced bronchospasm: 

Oral: 

  • Children 1 Month-6 Yrs: 75 Mcg/kg 3 Times A Day (max. Per Dose 2.5 Mg); 
  • 7-14 Years: 2.5 Mg 2-3 Times A Day; 
  • 15-17 Years: Initially 2.5 Mg 3 Times A Day, Then increased If Necessary To 5 Mg 3 Times A Day, 

Uncomplicated Premature Labour: 

By IV Infusion: 

  • Adult: Initially 5 Mcg/minute For 20 Minutes, Then Increased In Steps Of 2.5 Mcg/minute Every 20 Minutes Until Contractions Have Ceased (more Than 10 Mcg/minute Should Seldom Be Given; Should Not Be Exceeded20 Mcg/minute), Continue For 1 Hour, Then Reduced In Steps Of 2.5 Mcg/minute Every 20 Minutes To Lowestdose That Maintains Suppression (maximum Total Duration 48 Hours)

Content

  • Inj: Per ml: Terbutaline Sulphate 0.5mg; Amp.
  • Syp: Per ml: Terbutaline Sulphate 0.3mg.
  • Tab: Terbutaline Sulphate 2.5mg.

Pregnancy

Caution Advised

Stability

  • Beta 2-adrenoceptor Agonists

Contra Indications

  • When Used For Uncomplicated Premature Labour: Abruptio-placenta, Antepartum Haemorrhage, Cord Compression, Eclampsia, History Of Cardiac Disease, Intra-uterine Infection Or Fetal Death, Placenta Praevia, Pulmonary Hypertension, Severe Pre-eclampsia, Risk Factors For Myocardial Ischaemia, Threatened Miscarriage

Precautions

  • When Used For Uncomplicated Premature Labour: Abruptio-placenta, Antepartum Haemorrhage, Cord Compression, Eclampsia, History Of Cardiac Disease, Intra-uterine Infection Or Fetal Death, Placenta Praevia, Pulmonary Hypertension, Severe Pre-eclampsia, Risk Factors For Myocardial Ischaemia, Threatened Miscarriage

Lactation

  • Caution Advised

Side Effects

  • Muscle Tension
  • Nausea
  • Pulmonary Oedema (with Injection Use) Vomiting
  • Tremor
  • Peripheral Vasodilation
  • Tension
  • Headache
  • Sleep And Behavioural Disturbances In Children.

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