Generic Name
MetforminPacks Price
- Tab 250 mg(003718): 10x10: 99.33: 116.86
- Tab 500 mg(005310): 5x10: 71.83: 84.51
Biguanil
Therapeutic Group
Blood Glucose Lowering Drugs, Excluding InsulinIndication Dosage
Maturity-Onset Diabetes Mellitus, Monotherapy And In Combination With Insulin Or With Sulphonylureas Monotherapy:
- Adults: Initially 500 -850 Mg Two Or Three Times Daily During Or After Meals, Adjust Dose According To Response By Increasing 500 Mg Or 850 Mg After 10-15 Days; Max Dose 3g Daily.
With Insulin:
- Adults: Initially 500 Mg Daily, Increase 500 Mg Every Wk. Max: 2500 Mg/day. Decrease Insulin Dose 10-25% When Fasting Plasma Glucose Is Less Than the Desired Level.
- Children Above 10yrs: Initially 500 -850 Mg Once Daily During Or After Meals As Mono Therapy Or With Insulin, Adjust Dose After 10-15 Days According To Blood Glucose Level; Max Dose 2g Daily In 2-3 Divided Dose.
Content
- Tab 250mg /500mg /750mg /850mg /1gm: Metformin 250mg /500mg /750mg /850mg /1gm.
Pregnancy
Contraindicated Or Not Recommended.
Stability
- Biguanide
Contra Indications
- Acute Metabolic Acidosis Or Pre-coma, Hepatic Or Severe Renal (gfr<30ml/min) Impairment. Acute Conditions Predisposing To Renal Impairment, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Pregnancy, Lactation, And Elderly (above 75yrs).
Precautions
- Acute Metabolic Acidosis Or Pre-coma, Hepatic Or Severe Renal (gfr<30ml/min) Impairment. Acute Conditions Predisposing To Renal Impairment, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Pregnancy, Lactation, And Elderly (above 75yrs).
Lactation
- Contraindicated or Not Recommended.
Side Effects
- Reports Of Altered Lfts
- Hepatitis
- Gi Upset
- Taste Disturbance
- Skin Reactions
- Reduced B12 Absorptions
- Abnormal Liver Function Tests
- Rarely Lactic Acidosis.
Available Brands
Author
Shahid Arif