Generic Name
BuprenorphinePacks Price
- Inj : 5: 153.00: 180.00
Bubrifen
Therapeutic Group
OpioidsIndication Dosage
Moderate To Severe Pain:
By Sublingual Administration:
- Adult: 200-400 Mcg Every 6-8 Hours
- Children 6 Yrs & Above: (body-weight 16-25 Kg): 100 Mcg Every 6-8 Hours; (body-weight 25-37.5 Kg): 100-200 Mcg Every 6-8 Hours; (body-weight 37.5-50 Kg): 200-300 Mcg Every 6-8 Hours; (body-weight 50 Kg And Above): 200-400 Mcg Every 6-8 Hours
By IM Inj, Or By Slow IV Inj:
- Adult & Children Above 12 Yrs: 300-600 Mcg Every 6-8 Hours
- Children 6 Months-11 Yrs: 3-6 Micrograms/kg Every 6-8 Hours (max. Per Dose 9 Micrograms/kg)
Premedication:
By Sublingual Administration:
- Adult: 400 Mcg
By IM Inj:
- Adult: 300 Mcg
Intra-operative Analgesia:
By Slow IV Inj:
- Adult: 300-450 Mcg
Adjunct In The Treatment Of Opioid Dependence:
By Sublingual Administration:
- Adult: Initially 0.8-4 Mg For 1 Dose On The First Day, Adjusted In Steps Of 2-4 Mg Daily If Required; Usual Dose12-24 Mg Daily; Maximum 32 Mg Per Day
Content
- Inj Per 1 ml Amp: Buprenorphine Hci 0.324mg Equiv To 0.3mg Buprenorphine Base.
- Tab: Buprenorphine Hci 0.216mg Equiv To 0.2mg Buprenorphine Base.
Pregnancy
Risk Of Respiratory Depression And Withdrawal Symptoms In The Neonate, Risk Of Gastric Stasis And Inhalation Pneumonia In The Mother If Opioid Analgesics Are Used During Labour And Delivery
Stability
- Analgesic
- Opioids
Contra Indications
- Acute Respiratory Depression, Comatose Patients, Head Injury And Raised Intracranial Pressure (opioid Analgesics Interfere With Pupillary Responses Vital For Neurological Assessment), Risk Of Paralytic Ileus, Severe Renal Impairment; Avoid Use Or Reduce Dose; Opioid Effects Increased, Prolonged And Increased Cerebral Sensitivity Occurs.
Precautions
- Acute Respiratory Depression, Comatose Patients, Head Injury And Raised Intracranial Pressure (opioid Analgesics Interfere With Pupillary Responses Vital For Neurological Assessment), Risk Of Paralytic Ileus, Severe Renal Impairment; Avoid Use Or Reduce Dose; Opioid Effects Increased, Prolonged And Increased Cerebral Sensitivity Occurs.
Lactation
- Consult with Doctor Or Caution Advised
Side Effects
- Abdominal Pain
- Biliary Spasm
- Bradycardia
- Confusion
- Constipation
- Drug Dependence
- Difficulty With Micturition
- Dizziness
- Drowsiness
- Dry Mouth
- Dysphoria
- Euphoria
- Flushing
- Hallucinations
- Headache
- Miosis
- Nausea
- Oedema
- Palpitation
- Postural Hypotension
- Pruritus
- Rash
- Respiratory Depression
- Sexual Dysfunction
- Sleep Disturbances
- Sweating
- Tachycardia
- Ureteric Spasm
- Urinary Retention
- Urticaria
- Vertigo
- Visual Disturbances
- Vomiting
- Agitation
- Anorexia
- Anxiety
- Asthenia
- Diarrhoea
- Dyspepsia
- Dyspnea
- Fatigue
- Mild Withdrawal Symptoms In Patients Dependent On Opioids
- Paraesthesia
- Vasodilatation.
- Rare: Angina
- Diverticulitis
- Dysphagia
- Impaired Concentration
- Paralytic Ileus
- Psychosis
Available Brands
Author
Shahid Arif