Therapeutic Group

Indication Dosage

Phenytoin is a medication that is used to help control and prevent seizures in people who have epilepsy. It works by stabilizing electrical activity in the brain, which helps reduce the occurrence of seizures.

Tonic-clonic Seizures, Focal Seizures: 

• Children 1 Month-11 Yrs: Initially 1.5-2.5 Mg/kg Twice Daily, Then Adjusted According To Response To 2.5-5 Mg/kg Twice Daily (max. Per Dose 7.5 Mg/kg Twice Daily), Dose Also Adjusted According To Plasma Phenytoin Concentration; Maximum 300 Mg Per Day; 
• 12-17 Years: Initially 75-150 Mg Twice Daily, Then Adjusted According To Response To 150-200 Mg Twice Daily (max. Per Dose 300 Mg Twice Daily), Dose Also Adjusted According To Plasma-phenytoin Concentration 

Tonic-clonic Seizures, Focal Seizures, Prevention And Treatment Of Seizures During Or Following Neurosurgery Or Severe Head Injury: 

• Adult: Initially 3-4 Mg/kg Daily, Alternatively 150-300 Mg Once Daily Or In 2 Divided Doses; Usual Maintenance 200-500 Mg Daily, To Be Taken Preferably With Or After Food, Dose To Be Increased Gradually As Necessary (with Plasma Phenytoin Concentration Monitoring), Exceptionally, Higher Doses May Be Used If Needed 

Prevention And Treatment Of Seizures During Or Following Neuro Surgery Or Severe Head Injury: 

• Children: Initially 2.5 Mg/kg Twice Daily, Then Adjusted According To Response To 4-8 Mg/kg Daily, Dose Also Adjusted According To Plasma-phenytoin Concentration; Maximum 300 Mg Per Day 

Status Epilepticus, Acute Symptomatic Seizures Associated With Head Trauma Or Neurosurgery: 

By Slow IV Inj, Or By IV Infusion: 

• Adult: Loading Dose 20 Mg/kg (max. Per Dose 2 G), Then (by IV infusion Or Slow IV Injection Or Oral) Maintenance 100 Mg Every 6-8 Hours Adjusted According To Plasma-concentration Monitoring 
• Children 1 Month-11 Yrs: Loading Dose 20 Mg/kg, Then (by Slow IV Injection Or By IV Infusion) 2.5-5 Mg/kg Twice Daily; 
• 12-17 Yrs: Loading Dose 20 Mg/kg, Then (by IV infusion Or By Slow IV Injection) Up To 100 Mg 3-4 Times A Day

Content

Pregnancy

Avoid Unless The Potential Benefit Outweighs The Risk.

Stability

Contra Indications

Precautions

Lactation

Side Effects