Therapeutic Group

Indication Dosage

Divalproex Sodium is a medication used to treat seizures (epilepsy) and to prevent migraine headaches in adults and children. It helps control abnormal electrical activity in the brain, reducing the frequency of seizures and the intensity of migraines. Your doctor may prescribe it to you if you have these conditions to help manage them better.

All forms of Epilepsy, Complex Partial Seizures, and Absence Seizures: 

Oral: 

• Adult: Initial: 10-15 Mg/kg/day, Increase By 5-10 Mg/kg/wk. Max: 60 Mg/kg/day. 
• Children: Neonate: Initially 20 Mg/kg Once Daily; Usual Maintenance Dose 10 Mg/kg Twice Daily; 
• 1 Month-12 Yrs: Initially 10-15 Mg/kg (max 600 Mg) Daily In 1-2 Divided Doses; Usual Maintenance Dose 25-30 Mg/kg Daily In 2 Divided Doses (up To 60 Mg/kg Daily In 2 Divided Doses); 
• 12-18 Yrs: Initially 600 Mg Daily In 1-2 Divided Doses Increased Gradually (in Steps Of 150-300 Mg) Every 3 Days; Usual Maintenance Dose 1-2 Gm/day In 2 Divided Doses, Max 2.5 Gm/day In 2 Divided Doses. 

By IV Inj: 

• Adult: Initially 10 Mg/kg (usually 400-800 Mg) By IV Injection (over 3-5 Mins) Followed By IV Infusion Or IV Injection (over 3-5 Mins) In 2-4 Divided Doses Or By Continuous IV Infusion Up To Max 2.5 Gm Daily; Usual Range 1-2 Gm Dally(20-30 Mg/kg Daily). 
• Children: Neonate: 10 Mg/kg Twice Daily; 1 Month-12 Yr: Initially 10 Mg/ Kg By IV Injection, Followed By Continuous IV infusion, Or By Intermittent IV infusion Or IV Injection In 2-4 Divided Doses Up To the Usual Range of 20-40 Mg/kg Daily; 
• 12-18 Yr: Initially 10 Mg/ Kg By IV Injection, Followed By Continuous IV infusion, Or By Intermittent IV infusion Or IV Injection In 2-4 Divided Doses Up To Max 2.5 Gm Daily; Usual Range 1-2 Gm Daily (20-30 Mg/kg/ Day). 

Bipolar Disorder, Manic Episodes: 

• Oral: Adult: Initial: 750 Mg In Divided Doses, Increase Rapidly To Clinical Effect. Max: 60 Mg/kg/day. 

Migraine Prophylaxis: 

• Oral: Adult: Starting Dose 250 Mg Twice Daily, Some Patients May Benefit From Upto 1000 Mg/day.

Content

Pregnancy

Avoid Unless The Potential Benefit Outweighs The Risk.

Stability

Contra Indications

Precautions

Lactation

Side Effects