Glivec
Generic Name
Imatinib Mesylate
Packs Price
- Tab 100 mg(033196): 120: 153.065.15: 180.076.65
- Tab 100 mg(033196): 60: 68425.00: 80500.00
- Tab 400 mg(033197): 30: 136850.00: 161000.00
Company
Novartis
Therapeutic Group
Anti-neoplastics
Indication Dosage
Imatinib Mesylate is prescribed to treat certain types of leukemia and other rare blood disorders, as well as specific gastrointestinal stromal tumors (GISTs) in patients who require this targeted therapy.
Treatment Of Chronic Myeloid Leukaemia In Chronic Phase After Failure With Interferon Alfa:
- Adult: 400 Mg Once Daily, Increased If Necessary Up To 800 Mg Daily In 2 Divided Doses
Treatment Of Chronic Myeloid Leukaemia In Accelerated Phase, Or In Blast Crisis:
- Adult: 600 Mg Once Daily, Then Increased If Necessary Up To 800 Mg Daily In 2 Divided Doses
- Children Over 3 Yrs: 260 Mg/m2 Daily As A Single Dose Or In Two Divided Doses; Max 400 Mg Daily; In Advanced Phase:340 Mg/m2 Daily As A Single Dose Or In Two Divided Doses; Max 600 Mg Daily.
Treatment Of Newly Diagnosed Acute Lymphoblastic Leukaemia (in Combination With Other Chemotherapy), Monotherapy For Relapsed Or Refractory Acute Lymphoblastic Leukaemia:
Treatment Of C-kit (cd117)-positive Unresectable Or Metastatic Malignant Gastro-intestinal Stromal Tumours (gist), Adjuvant Treatment Following Resection Of C-kit (cd117)-positive Gist, In Patients At Significant Risk Of Relapse, Treatment Of myelodysplastic/myeloproliferative Diseases Associated with Platelet-derived Growth Factor Receptor Gene rearrangement:
Treatment Of Unresectable Dermatofibrosarcoma Protuberans, Recurrent Or Metastatic Dermatofibrosarcoma Protuberans, When Surgery Is Not Possible:
- Adult: 800 Mg Daily In 2 Divided Doses
Treatment Of Advanced Hypereosinophilic Syndrome And Chronic Eosinophilic Leukaemia:
- Adult: 100-400 Mg Once Daily
Content
- Cap /Tab 100mg /400mg: Imatinib (as Mesylate) 100mg /400mg.
Pregnancy
Positive Evidence Of Risk: Avoid
Stability
- Bcr-abl Tyrosine Kinase Inhibitor
Contra Indications
Precautions
Lactation
- Contraindicated. Discontinue Breast-feeding
Side Effects
- Abdominal Pain
- Arthralgia
- Ascites
- Conjunctivitis
- Cramps
- Gi Upset
- Dry Eyes
- Mouth
- And Skin
- Dyspnea
- Epistaxis
- Fatigue
- Flushing
- Gastro-oesophageal Reflux
- Haemorrhage
- Headache
- Hypoaesthesia
- Increased Lacrimation
- Influenza-like Symptoms
- Insomnia
- Oedema
- Paraesthesia
- Photosensitivity
- Pleural Effusion
- Pruritus
- Pulmonary Oedema
- Rash
- Sweating
- Taste Disturbance
- Visual Disturbances
- Weight Changes
- Acute Respiratory Failure
- Depression
- Drowsiness
- Dysphagia
- Gout
- Gynaecomastia
- Haematoma
- heart Failure
- Hepatic Dysfunction
- Hepatitis
- Hypertension
- Hypotension
- Impaired Memory
- Menorrhagia
- Migraine
- Palpitation
- Pancreatitis
- Peripheral Neuropathy
- Renal Failure
- Sexual Dysfunction
- Skin Hyperpigmentation
- Syncope
- Tachycardia
- Tinnitus
- Tremor
- Urinary Frequency
- Vertigo
- Alopecia
- Bone-marrow Suppression
- Growth Retardation In Children
- Hepatitis B Reactivation
- Hyperuricaemia
- Oral Mucositis
- Thromboembolism
- Tumourlysis Syndrome
- Vomiting.
- Rare: Hepatic Failure (fatal Cases Reported)
- Hepatic Necrosis
- Rhabdomyolysis
- Stevens-johnson Syndrome