Adult: Initially 1.25-2.5 Mg Once Daily, Increased If Necessary Up To 10 Mg Once Daily, Increased At Intervals Of 2-4 Weeks
Symptomatic Heart Failure (adjunct):
Adult: Initially 1.25 Mg Once Daily, Increased If Tolerated To 10 Mg Daily In 2 Divided Doses, Increase Dose Gradually At Intervals Of 1-2 Weeks
Prophylaxis After Myocardial Infarction In Patients With Clinical Evidence Of Heart Failure (started At Least 48 Hours After Infarction):
Adult: Initially 2.5 Mg Twice Daily For 3 Days, Then Increased To 5 Mg Twice Daily, If Initial Dose Not Tolerated Then 1.25 Mg Twice Daily For 2 Days, Then Increased To 2.5 Mg Twice Daily, Then Increased To 5 Mg Twice Daily, Withdraw Treatment If Dose Cannot Be Increased To 2.5 Mg Twice Daily
Prevention Of Cardiovascular Events In Patients With Atherosclerotic Cardiovascular Disease Or With Diabetes Mellitus And An Additional Risk Factor For Cardiovascular Disease:
Adult: Initially 2.5 Mg Once Daily For 1-2 Weeks, Then Increased To 5 Mg Once Daily For A Further 2-3 Weeks, Then Increased To 10 Mg Once Daily
Nephropathy:
Adult: Initially 1.25 Mg Once Daily For 2 Weeks, Then Increased To 2.5 Mg Once Daily For A Further 2 Weeks, Then Increased If Tolerated To 5 Mg Once Daily