Therapeutic Group
Other Beta-Lactam, Cephalosporins & Penems
Indication Dosage
Pneumonia, Intra-abdominal Infections, Complicated Genitourinary Tract Infections, Severe Infection Of Respiratory Tract, Acute Exacerbations Of Chronic Obstructive Pulmonary Disease:
By IV Infusion, OrIV Inj, Or Deep IM Inj:
- Adult: 1-2 G Once Daily, 2 G Dose To Be Used Forhospital-acquired Pneumonia And Severe Cases
Complicated Skin And Soft Tissue Infections, Infections Of Bones And Joints:
By IV Infusion, OrIV Inj, Or Deep IM Inj:
Suspected Bacterial Infection In Neutropenic Patients:
By IV Infusion, OrIV Inj, Or Deep IM Inj:
- Adult: 2-4 G Once Daily, Higher Doses Used In Severe Cases
Bacterial Meningitis, Bacterial Endocarditis:
By IV Infusion, Or IV Inj, Or Deep IM Inj:
- Adult: 2-4 G Once Daily, Higher Doses Used In Severe Cases
By IV Infusion Or Deep IM Inj:
- Children 1 Month-11 Years (body-weight Up To50 Kg): 80-100 Mg/kg Once Daily, 100 Mg/kg Once Daily; Maximum 4 G Per Day;
- 9-17 Years (body weight 50 Kg And Above): 2-4 Gonce Daily, Higher Doses Used In Severe Cases
By IV Inj:
- Children 9-17 Years (body weight 50 Kg And Above): 2-4 Gonce Daily, Higher Doses Used In Severe Cases
Surgical Prophylaxis:
By IV Infusion, Or IV Inj, Or Deep IM Inj:
- Adult: 2 G For 1 Dose, Administered30-90 Minutes Before Procedure
Uncomplicated Gonorrhea, Pelvic Inflammatory Disease:
By Deep IM Inj:
Syphilis:
By IV Infusion, Or IV Inj, Or Deep IM Inj:
- Adult: 0.5-1 G Once Daily For 10-14 Days, Dose Increased To 2 G Once Daily For Neurosyphilis
Disseminated Lyme Borreliosis (stages II & III)
By IV Infusion, Or IV Inj, Or Deep IM Inj:
- Adult: 2 G Once Daily For 14-21 Days
Prevention Of Secondary Case Of Meningococcal Meningitis
By IM Inj:
Prevention Of Secondary Case Of Haemophilus Influenza Type B Disease:
By IM Inj, Or IV Inj, Or Iv Infusion:
- Adult: 1 G Daily For 2 Days
Acute Otitis Media:
By Deep IM Inj:
- Adult: 1-2 G For 1 Dose, Dose Can Be Given For 3 Days If severely Ill Or Previous Therapy Failed.
- Children: 50 Mg/kg Single Dose. Max: 1 Gm/dose.
Content
- IM Inj 250mg /500mg /1gm: Ceftriaxone 250mg /500mg /1gm (as Sodium); Powder In Vial.
- IV Inj 250mg /500mg /1gm /2gm: Ceftriaxone 250mg /500mg /1gm /2gm (as Sodium); Powder In Vial.
Pregnancy
No Evidence Of Harm
Stability
- Cephalosporin Antibiotics
Contra Indications
- Beta-lactam Hypersensitivity. Premature Newborns Having Less Than 41 Weeks Postmenstrual Age; Neonates Over 41 Weeks Postmenstrual Age With Jaundice, Hypoalbuminaemia Or Acidosis; Concomitant Treatment With Iv Calcium (including Total Parenteral Nutrition Containing Calcium) In Neonates Over 41 Weeks Postmenstrual Age -risk Of Precipitation In Urine And Lung. Do Not Use In Hyper-bilirubinaemia Neonates.
Precautions
- Beta-lactam Hypersensitivity. Premature Newborns Having Less Than 41 Weeks Postmenstrual Age; Neonates Over 41 Weeks Postmenstrual Age With Jaundice, Hypoalbuminaemia Or Acidosis; Concomitant Treatment With Iv Calcium (including Total Parenteral Nutrition Containing Calcium) In Neonates Over 41 Weeks Postmenstrual Age -risk Of Precipitation In Urine And Lung. Do Not Use In Hyper-bilirubinaemia Neonates.
Lactation
- Consult with Doctor Or Caution Advised
Side Effects
- Abdominal Discomfort
- Agranulocytosis
- Allergic Reactions
- Anaphylaxis
- Aplastic Anaemia
- Blood Disorders
- Confusion
- Disturbances In Liver Enzymes
- Dizziness
- Eosinophilia
- Haemolytic Anaemia
- Hallucinations
- Headache
- Hypertonia
- Leucopenia
- Nervousness
- Pruritus
- Rashes
- Fever And Arthralgia
- Sleep Disturbances
- Urticaria
- Gi Disturbances
- Rare: Stevens-johnsonsyndrome
- Thrombocytopenia
- Toxic Epidermal Necrolysis
- Transient Cholestatic Jaundice
- Transient Hepatitis