Generic Name
FinerenonePacks Price
- -
Kerendia
Therapeutic Group
Endocrine Hormone TherapyIndication Dosage
Indication:
Finerenone is primarily indicated for adults with chronic kidney disease (CKD) associated with type 2 diabetes. It is used to:
- Reduce the risk of sustained decline in estimated glomerular filtration rate (eGFR).
- Lower the chances of end-stage kidney disease (ESKD).
- Decrease the risk of cardiovascular events such as non-fatal myocardial infarction and hospitalization for heart failure.
Dosage:
- The initial recommended dose of Finerenone is 10 mg or 20 mg once daily, based on the patient’s kidney function (eGFR).
- If the eGFR is ≥60 mL/min/1.73 m², start with 20 mg once daily.
- If the eGFR is between 25-60 mL/min/1.73 m², start with 10 mg once daily.
- The dose can be adjusted based on the patient’s potassium levels and kidney function during treatment.
Note: Regular monitoring of serum potassium levels and kidney function is essential to adjust the dose and ensure safe usage of the medication.
Content
- 10 mg Tablets
- 20 mg Tablets
Pregnancy
Not Recommended
Stability
- mineralocorticoid receptor antagonist (MRA)
Contra Indications
- Finerenone is contraindicated in patients with known hypersensitivity to the drug, severe hyperkalemia (potassium levels > 5.5 mEq/L), and severe renal impairment (eGFR < 25 mL/min/1.73 m²). It should also be avoided in individuals using other potassium-sparing medications or strong CYP3A4 inhibitors due to an increased risk of hyperkalemia.
Precautions
- Finerenone is contraindicated in patients with known hypersensitivity to the drug, severe hyperkalemia (potassium levels > 5.5 mEq/L), and severe renal impairment (eGFR < 25 mL/min/1.73 m²). It should also be avoided in individuals using other potassium-sparing medications or strong CYP3A4 inhibitors due to an increased risk of hyperkalemia.
Lactation
- Not Recommended
Side Effects
- Hyperkalemia
- Hypotension
- Renal dysfunction
- Gastrointestinal issues
- Fatigue
Author
Shahid Arif