Desmopressin is a medication primarily prescribed to manage conditions characterized by excessive urination and fluid loss, such as diabetes insipidus and certain cases of nocturnal enuresis (bedwetting). It works by regulating water balance in the body, reducing urine production, and preventing dehydration in individuals with these conditions.
Diabetes Insipidus, Treatment:
Oral:
Adult: Initially 100 Mcg 3 Times A Day; Maintenance 100-200 Mcg 3 Times A Day; Usual Dose 0.2-1.2 Mg Daily
Children 1-23 Months: Initially 10 Mcg 2-3 Times A Day, Adjusted According To Response; Usual Dose 30-150 Mcg Daily;
2-11 Years: Initially 50 Mcg 2-3 Times A Day, Adjusted According To Response; Usual Dose 100-800 Mcg Daily;
12-17 Years: Initially 100 Mcg 2-3 Times A Day, Adjusted According To Response; Usual Dose 0.2-1.2 Mg Daily
By Intranasal Spray:
Adult: 10-40 Mcg Daily In 1-2 Divided Doses
Children 1-23 Months: Initially 2.5-5 Mcg 1-2 Times A Day, Adjusted According To Response;
2-11 Years: Initially 5-20 Mcg 1-2 Times A Day, Adjusted According To Response;
12-17 Years: Initially 10-20 Mcg 1-2 Times A Day, Adjusted According To Response
By Sc Inj, Or By IV Inj, Or By IM Inj:
Adult: 1-4 Mcg Daily
Primary Nocturnal Enuresis:
Adult 18-65 Years: 200 Mcg Once Daily At Bedtime, Increased To 400 Mcg Only If Lower Dose Not Effective; Withdraw 1 Week Before Reassessment After 3 Months, Limit Fluid Intake From 1 Hour Before To 8 Hours After Administration
Children 5-17 Years: 200 Mcg Once Daily At Bedtime, Increased To 400 Mcg Only If Lower Dose Not Effective; Withdraw 1 Week Before Reassessment After 3 Months, Limit Fluid Intake From 1 Hour Before To 8 Hours After Administration
Postoperative Polyuria Or Polydipsia:
Adult: Adjusted Dose According To Urine Osmolality
Adult: 20 Mcg, Limit Fluid Intake To 500ml From 1 Hour Before To 8 Hours After Administration
By IM Inj, Or By Sc Inj:
Adult: 2 Mcg For 1 Dose, Limit Fluid Intake To500ml From 1 Hour Before To 8 Hours After Administration
Nocturia Associated With Multiple Sclerosis (when Other Treatments Have Failed):
By Intranasal Spray:
Adult 18-65 Years: 10-20 Mcg Once Daily, To Be Taken At Bedtime, Dose Not To Be Repeated Within 24 Hours, Limit Fluid Intake From 1 Hour Before To8 Hours After Administration
Renal Function Testing:
By Intranasal Spray:
Adult: 40 Mcg, Empty Bladder At Time Of Administration And Limit Fluid Intake To 500ml From 1 Hour Before Until 8 Hours After Administration To Avoid Fluid Overload
By Sc Inj, Or By IM Inj:
Adult: 2 Mcg, Empty Bladder At Time Of Administration And Restrict Fluid Intake To 500ml From1 Hour Before Until 8 Hours After Administration To Avoid Fluid Overload
Mild To Moderate Haemophilia And Von Willebrand's Disease:
By Intranasal Spray:
Adult: 300 Mcg Every 12 Hours If Required, One 150 Mcg Spray Into Each Nostril, 30 Minutes Before Surgery Or When Bleeding, The Dose May Alternatively Be Repeated At Intervals Of At Least 3 Days, If Self-administered
By IV Infusion, Or By Sc Inj:
Adult: 300 Nanograms/kg For 1 Dose, To Be Administered Immediately Before Surgery Or After Trauma; May Be Repeated At Intervals Of 12 Hours
Fibrinolytic Response Testing:
By Intranasal Spray:
Adult: 300 Mcg, Blood To Be Sampled After1 Hour For Fibrinolytic Activity, One 150 Mcg Spray To Be Administered Into Each Nostril
By Sc Inj, Or By IV Inj:
Adult: 300 Nanograms/kg For 1 Dose, Blood To Besampled After 20 Minutes For Fibrinolytic Activity
Lumbar-puncture-associated Headache:
By IM Inj, Or By Sc Inj:
Adult: (consult Product Literature)
Content
Inj 4 Mcg /15 Mcg: Per ml: Desmopressin Acetate 4 Mcg /15 Mcg; 1 ml Amp.
Tab 0.1mg /0.2mg: Desmopressin 100 Mcg /200 Mcg.
Spray 0.01mg: Per Dose: Desmopressin 10 Mcg; 2.5 ml Solution.
Pregnancy
Caution Advised
Stability
Pituitary & Hypothalamic Hormones & Analogues
Vasopressin Analogue
Contra Indications
Cardiac Insufficiency, Conditions Treated With Diuretics, History Of Hyponatraemia, Polydipsia In Alcohol Dependence, Psychogenic Polydipsia, Syndrome Of Inappropriate Adh Secretion (in Adults) Habitual, Psychogenic Polydipsia, Cardiac Insufficiency, Other Conditions Requiring Diuretic Treatment.
Precautions
Cardiac Insufficiency, Conditions Treated With Diuretics, History Of Hyponatraemia, Polydipsia In Alcohol Dependence, Psychogenic Polydipsia, Syndrome Of Inappropriate Adh Secretion (in Adults) Habitual, Psychogenic Polydipsia, Cardiac Insufficiency, Other Conditions Requiring Diuretic Treatment.
Lactation
Caution Advised
Side Effects
Hyponatraemia With Convulsions On Administration Without Restricting Fluid Intake