Generic Name
Glyceryl TrinitratePacks Price
- Cap SR 2.6 mg: 2x15: 173.40: 204.00
- CapR 6.4 mg: 3x10: 204.85: 241.00
- Tab SR 2.6(090197): 30: 165.75: 195.00
Niglys
Therapeutic Group
Cardiac TherapyIndication Dosage
Glyceryl Trinitrate, commonly known as nitroglycerin, is a medication indicated for the treatment of angina pectoris, a condition characterized by chest pain or discomfort due to reduced blood flow to the heart muscle. It works by relaxing and dilating the blood vessels, which helps to increase blood flow to the heart, thereby relieving the pain and reducing the workload on the heart. Glyceryl Trinitrate is an essential therapeutic option for individuals with angina to manage their symptoms and improve their overall quality of life.
Treatment Or Prophylaxis Of Angina:
By Sublingual Aerosol Spray:
- Adult: 1-2 Sprays, Dose Be Administered Under Tongue And Then Close Mouth
Oral:
- Adults: 2.5-9 Mg 2-4 Times Daily Up To 26 Mg 4 Times/day.
- Children: Not Recommended.
By Tab Buccal:
- Adults: Initial 1 Mg Every 3-5 hours while Awake (3 Times a Day), Increase Dose Upward If Angina Occurs With Tablet In Place.
- Children: Not Recommended.
By Sublingual Tablets:
- Adults: 0.2-0.6 Mg Every 5 Min For Max Of 3 Doses In 15 Min; May Also Be Used Prophylactically 5-10 Min Prior To Activities Which May Provoke An Attack.
- Children: Not Recommended.
Transdermal Patch:
- Adults: Initial 0.2-0.4 Mg/hr, Increase To Doses Of 0.4-0.8 Mg/hr; Tolerance Is Minimized By Using A Patch-on Period Of 12-14 Hr And Patch-off Period Of 10-12 Hr.
- Children: Not Recommended.
Control Of Hypertension And Myocardial Ischaemia During And After Cardiac Surgery, Induction Of Controlled Hypotension During Surgery, Congestive Heart Failure, Unstable Angina:
By IV Infusion:
- Adult: 10-200 Mcg/min (max. Per Dose 400 Mcg/min), Adjusted According To Response, Consult Product Literature For Recommended Starting Doses Specific To Indication
Pulmonary Hypertension:
- Children: Initially 0.25-0.5 Mcg/kg/min And Increase By 1 Mcg/kg/min At 20 To 60 Min Intervals To Desired Effect. Usual Dose: 1-3 Mcg/kg/min; Max 5 Mcg/kg/min.
Content
- Aerosol Spray (translingual): Glyceryl Trinitrate 0.4mg /metered Spray; Approx 200 Sprays.
- Cap Sustained Release 0.5mg /2.5mg /2.6mg /6.4mg /6.5mg: Glyceryl Trinitrate 0.5mg /2.5mg /2.6mg /6.
Pregnancy
Caution Advised, Risk Cannot Be Ruled Out.
Stability
- Nitrate
Contra Indications
- Glaucoma, Hypovolaemia, Hypertrophic Cardiomyopathy, Aortic Or Mitral Stenosis, Cardiac Tamponade, Constrictive Pericarditis, Toxic Pulmonary Oedema, Head Trauma, Cerebral Haemorrhage, Cerebrovascular Disease, Marked Anaemia, Raised Intracranial Pressure, Hypersensitivity To Nitrates.
Precautions
- Glaucoma, Hypovolaemia, Hypertrophic Cardiomyopathy, Aortic Or Mitral Stenosis, Cardiac Tamponade, Constrictive Pericarditis, Toxic Pulmonary Oedema, Head Trauma, Cerebral Haemorrhage, Cerebrovascular Disease, Marked Anaemia, Raised Intracranial Pressure, Hypersensitivity To Nitrates.
Lactation
- Caution Advised.
Side Effects
- Tachycardia
- Bradycardia
- Headache
- Dizziness
- Collapse
- Hypotension
- Nausea
- Vomiting
- Palpitation
- Metabolic Acidosis
- Heartburn
- Flushing
- Syncope
- Temporary Hypoxaemia
- Rash
- Application Site Reactions With Transdermal Patches
- Urinary And Fecal Incontinence
- Very Rarely Angle-closure Glaucoma. Injection Specific Side-effects Include Severe Hypotension
- Diaphoresis
- Apprehension
- Restlessness
- Muscle Twitching
- Retrosternal Discomfort
- Palpitation
- Abdominal Pain; Methaemolobinaemia.
Available Brands
Author
Shahid Arif