Therapeutic Group

Indication Dosage

Palonosetron is a medication used to prevent nausea and vomiting caused by chemotherapy or surgery. It works by blocking the action of a chemical in the brain called serotonin, which can trigger nausea and vomiting.

Moderate To Severe Emetogenic Chemotherapy: 

By IV Inj: 

• Adult: 250 Mcg To Be Administered Over 30 Seconds, Given As A Single Dose, 30

Minutes Prior To Chemotherapy. 

• Children 1 Month To Adolescents: 20mcg/kg/dose Iv (max: 1.5mg/dose) Infused Over 15 Minutes As A Single Dose 30 Minutes Prior To Chemotherapy. 

Chemotherapy-induced Nausea/vomiting (CINV) Prophylaxis Associated With Initial And Repeat Courses Of Emetogenic Cancer Chemotherapy: 

By IV Inj: 

• Adult: 250 Mcg To Be Administered Over 30 Seconds, Given As A Single Dose, 30 Minutes Prior To Chemotherapy. 
• Children 1 Month To Adolescents: 20mcg/kg/dose Iv (max: 1.5mg/dose) Infused Over 15 Minutes As A Single Dose 30 Minutes Prior To Chemotherapy. 

For Post-Operative Nausea/vomiting (PONV) Prophylaxis For Up To 24 Hours After Surgery: 

By IV Inj: 

• Adult: 0.075mg Iv Single Dose Administered Over 10 Seconds Immediately Before The Induction Of Anesthesia. 

Maximum Dose Ranges That Can Be Administered Are Given Below: 

• Adults: 0.25mg Iv Or 0.5mg Po As A Single Dose. 
  Geriatric: 0.25mg Iv Or 0.5mg Po As A Single Dose. 
  Adolescents: 20mcg/kg/dose Iv (max: 1.5mg/dose). 
  Children: 20mcg/kg/dose Iv (max: 1.5mg/dose). 
  Infants: 20mcg/kg/dose Iv.

Content

Pregnancy

Avoid

Stability

Contra Indications

Precautions

Lactation

Side Effects