Recormon

Therapeutic Group

Indication Dosage

Indication:

Epoetin Beta is a medication used to treat anaemia, which is a condition where your body doesn't have enough red blood cells. It's often given to people with kidney problems or those undergoing certain cancer treatments to help boost their red blood cell production and improve their energy levels and overall well-being.

Dosage:

Symptomatic Anaemia Associated With Chronic Renal Failure: 

By Sc Inj: 

• Adult: Initially 20 Units/kg 3 Times A Week For 4 Weeks, Increased In Steps Of 20 Units/kg 3 Times A Week, According To Response At Intervals Of 4 Weeks, Total Weekly Dose May Be Divided Into Daily Doses; Maintenance Dose, Initially Reduce Dose By Half Then Adjust According To Response At Intervals Of 1-2 Weeks, Total Weekly Maintenance Dose May Be Given As A Single Dose Or In 3 Or 7 Divided Doses. Subcutaneous Route Preferred In Patients Not On Haemodialysis. Reduce Dose By Approximately 25% If Rise In Haemoglobin Concentration Exceeds 2 G/100ml Over 4 Weeks Or If Haemoglobin Concentration Approaches Or Exceeds 12 G/100 Ml; If Haemoglobin Concentration Continues To Rise, Despite Dose Reduction, Suspend Treatment Until Haemoglobin Concentration Decreases And Then Restart At A Dose Approximately 25% Lower Than The Previous Dose; Maximum 720 Units/kg Per Week 

By IV Inj: 

• Adult: Initially 40 Units/kg 3 Times A Week For 4 Weeks, then Increased To 80 Units/kg 3 Times A Week, Then Increased In Steps Of 20 Units/kg 3 Times A Week If Required, At Intervals Of 4 Weeks; Maintenance Dose, Initially Reduce Dose By Half Then Adjust According To Response At Intervals Of 1-2 Weeks. Intravenous Injection To Be Administered Over 2 Minutes, Subcutaneous Route Preferred In Patients Not On Haemodialysis. Reduce Dose By Approximately 25% If Rise In Haemoglobin Concentration Exceeds 2 G/100ml Over 4 Weeks Or If Haemoglobin Concentration Approaches Or Exceeds 12 G/100 Ml; If Haemoglobin Concentration Continues To Rise, Despite Dose Reduction, Suspend Treatment Until Haemoglobin Concentration Decreases And Then Restart At A Dose Approximately 25% Lower Than The Previous Dose; Maximum 720 Units/kg Per Week 

Symptomatic Anaemia In Adults With Non-myeloid Malignancies Receiving Chemotherapy: 

By Sc Inj: 

• Adult: Initially 450 Units/kg Once Weekly For 4 Weeks, Dose To Be Given Weekly As A Single Dose Or In 3-7 Divided Doses, Increase Dose After 4 Weeks (if A Rise In Haemoglobin Of At Least 1 G/100ml Not Achieved), Increased To 900 Units/kg Once Weekly, Dose To Be Given Weekly As A Single Dose Or In 3-7 Divided Doses, If Adequate Response Obtained Reduce Dose By 25-50%, Discontinue Treatment If Haemoglobin Concentration Does Not Increase By At Least 1 G/100ml After 8 Weeks Of Therapy (response Unlikely). Reduce Dose By Approximately 25-50% If the Rise In Haemoglobin Concentration Exceeds 2 G/100 Ml Over 4 Weeks Or If Haemoglobin Concentration Exceeds 12 G/100 Ml; If Haemoglobin Concentration Continues To Rise, Despite Dose Reduction, Suspend Treatment Until Haemoglobin Concentration Decreases And Then Restart At A Dose Approximately 25% Lower Than The Previous Dose. Discontinue Approximately 4 Weeks After Ending Chemotherapy; Maximum 60 000 Units Per Week

Content

Pregnancy

Benefits Probably Outweigh Risk Of Anaemia And Of Blood Transfusion In Pregnancy.

Stability

Contra Indications

Precautions

Lactation

Side Effects