Generic Name
ClozapinePacks Price
- Tab 100 mg (050827): 5x10: 1710.62: 2012.50
- Tab 25 mg (038920): 5x10: 340.00: 400.00
U-Sazine
Therapeutic Group
Psycholeptics (Antipsychotic, Anxiolytic/Hypnotic)Indication Dosage
Clozapine is a medication used to treat severe mental illnesses, especially when other medications haven't worked well enough. It's prescribed for conditions like schizophrenia to help manage symptoms such as hallucinations, delusions, and disturbances in thinking. Clozapine can be a helpful option when other treatments haven't been effective in controlling these symptoms.
Schizophrenia In Patients Unresponsive To, Or Intolerant of, Conventional Antipsychotic Drugs:
- Adult 18-59 Yrs: 12.5 Mg 1-2 Times A Day For Day 1, then 25-50 Mg For Day 2, Then Increased, If Tolerated, In Steps Of 25-50 Mg Daily, Dose To Be Increased Gradually Over 14-21 Days, Increased To Up To 300 Mg Daily In Divided Doses, Larger Dose To Be Taken At Night, up To 200mg Daily May Be Taken As A Single Dose Atbedtime; Increased In Steps Of 50-100 Mg Preferably To Increase Once A Week; Usual Dose 200-450 Mg Daily, Max. 900mg Perday, If Restarting After Interval Of More Than 48 Hours,12.5 Mg Once Or Twice On First Day (but May Be Feasible to Increase More Quickly Than On Initiation)
- Adult 60 Yrs And Over: 12.5 Mg Once Daily For Day 1, then Increased To 25-37.5 Mg For Day 2, Then Increased, if Tolerated, In Steps Of Up To 25 Mg Daily, Dose To Be Increased Gradually Over 14-21 Days, Increased To Up To300 Mg Daily In Divided Doses, Larger Dose At To Be Taken Night, Up To 200mg Daily May Be Taken As A Single Dose At Bedtime; Increased In Steps Of 50-100 Mg Preferably To Increase Once A Week; Usual Dose 200-450 Mg Daily, Max. 900mg Perday
Psychosis In Parkinson's Disease:
- Adult: 12.5 Mg Once Daily, Dose To Be Taken At Bedtime, then Increased In Steps Of 12.5 Mg Up To Twice Weekly, adjusted According To Response; Usual Dose 25-37.5 Mg Once Daily, Dose To Be Taken At Bedtime; Increased Insteps Of 12.5 Mg Once Weekly, Increased If Necessary Up To 100 Mg Daily In 1-2 Divided Doses; Usual Maximum 50 Mg/24 Hours
Content
- Tab 25mg /100mg: Clozapine 25mg / 100mg.
Pregnancy
Caution Advised
Stability
- Dibenzodiazepine
Contra Indications
- Severe Cardiac Disorders(e.g. Myocarditis), Severe Cns Depression, Uncontrolledepilepsy, Alcoholic And Toxic Psychoses, Bone-marrow Disorders,coma, Drug Intoxication, History Of Agranulocytosis, History Of Circulatory Collapse, History Of Neutropenia,paralytic Ileus
Precautions
- Severe Cardiac Disorders(e.g. Myocarditis), Severe Cns Depression, Uncontrolledepilepsy, Alcoholic And Toxic Psychoses, Bone-marrow Disorders,coma, Drug Intoxication, History Of Agranulocytosis, History Of Circulatory Collapse, History Of Neutropenia,paralytic Ileus
Lactation
- Contraindicated
Side Effects
- Anorexia
- Hypersalivation
- Agranulocytosis
- Constipation
- Malaise
- Speech Disorders
- Urinary Incontinence
- Hepatic Disorders
- Hepatic Failure
- Muscle Disorders
- Renal Failure.
- Rare: Circulatory Collapse
- Dysphagia
- Hepatitis
- Myocarditis
- Pancreatitis
- Pericarditis
- Pneumonia
- Pulmonary Aspiration
Available Brands
Author
Shahid Arif