Alendronate

Therapeutic Group

Drugs For Treatment Of Bone Diseases

Indication Dosage

Treatment Of Postmenopausal Osteoporosis 

  • Adult (Female): 10 Mg Daily, Alternatively 70 Mg Once Weekly. The Tablet Should Be Taken Upon Arising With A Full Glass Of Water, 30 Min Before Food, Drink Or Other Oral Medications. Remain Upright For 30 Min After Dose. 

Treatment Of Osteoporosis In Men: 

  • Adult (Male): 10 Mg Daily. The Tablet Should Be Taken Upon Arising With A Full Glass Of Water, 30 Min Before Food, Drink Or Other Oral Medications. Remain Upright For 30 Min After Dose. 

Prevention And Treatment Of Corticosteroid-induced Osteoporosis In Postmenopausal Women Not Receiving Hormone Replacement Therapy: 

  • Adult (Female): 10 Mg Daily. The Tablet Should Be Taken Upon Arising With A Full Glass Of Water, 30 Min Before Food, Drink Or Other Oral Medications. Remain Upright For 30 Min After Dose.

Content

  • Tab 10mg: Alendronate Sodium Equiv 10mg Alendronic Acid.
  • OW (Once Weekly) Tab 70mg: Alendronate Sodium Equiv 70mg Alendronic Acid.

Pregnancy

Contraindicated

Stability

  • Bisphosphonate

Contra Indications

  • Renal Impairment With Gfr <35 Ml/min, Oesophageal Abnormalities, Stricture, Achalasia Or Inability To Remain Upright For 30 Min After Dosing, Hypocalcaemia.

Precautions

  • Renal Impairment With Gfr <35 Ml/min, Oesophageal Abnormalities, Stricture, Achalasia Or Inability To Remain Upright For 30 Min After Dosing, Hypocalcaemia.

Lactation

  • Contraindicated

Side Effects

  • Abdominal Distension And Pain
  • Constipation
  • Diarrhoea
  • Dyspepsia
  • Flatulence
  • Headache
  • Oesophageal Reactions (oesophagitis
  • Oesophageal Ulcers
  • Oesophageal Stricture And Oesophageal Erosions)
  • Regurgitation
  • Musculoskeletal Pain
  • Episcleritis
  • Erythema
  • Gastritis
  • Nausea
  • Rash
  • Scleritis
  • Uveitis
  • Vomiting.
  • Rare: Atypical Femoral Fractures With Long-term Use
  • Hypocalcaemia
  • Osteonecrosis Of The Jaw
  • Photosensitivity
  • Severe Skin Reactions
  • Stevens-johnson Syndrome
  • Toxic Epidermal Necrolysis
  • Upper Gastro-intestinal Ulcers

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