Alprostadil

Therapeutic Group

Erectile Dysfunction Products

Indication Dosage

Alprostadil is a medication primarily indicated for the treatment of erectile dysfunction (ED). It works by relaxing the blood vessels and muscles in the penis, allowing for increased blood flow, which in turn helps men achieve and sustain an erection. Additionally, Alprostadil is also used in some cases to treat infants with certain heart conditions and to diagnose or treat specific vascular issues in adults.

Aid To Diagnosis And Treatment Of Erectile Dysfunction: 

By Intracavernosal Inj: 

  • Adults: Initially 2.5 Mcg By Intra-cavernosal Injection. If Necessary Increase In 2.5 Mcg Increments To Max 60 Mcg. Max Frequency Of Use, Once Daily And 3 Times Per Wk. 
  • Children: Not Applicable. 

By Urethral Application: 

  • Adults: Initially 250 Mcg Intraurethral Suppository Administration. Increase Or Decrease For Subsequent Doses According To Response. Max 2 Doses In 24 hours and Not More Than 7 Doses In 7 Days. See Literature. 
  • Children: Not Recommended.

Content

  • Inj 10 Mcg /20 Mcg: Alprostadil 10 Mcg /20 Mcg; Powder In Vial Plus Diluent In Pre-Filled Syringe, Needles. Urethral Suppository 125 Mcg /250 Mcg /500 Mcg /1mg: Alprostadil 125 Mcg /250 Mcg /500 Mcg

Pregnancy

Consult with Doctor Or Caution Advised

Stability

  • Prostaglandin

Contra Indications

  • Penile Implants Or When Sexual Activity Medically Inadvisable (e.g. Orthostatic Hypotension, Myocardial Infarction, And Syncope), Not For Use With Other Agents For Erectile Dysfunction, Predisposition To Prolonged Erection (as In Thrombocythemia, Polycythemia, Sickle Cell Anaemia, Multiple Myeloma Or Leukaemia). Urethral Application Is Contra-indicated In Balanitis, Severe Curvature, Severe Hypospadias, Urethral Stricture And Urethritis

Precautions

  • Penile Implants Or When Sexual Activity Medically Inadvisable (e.g. Orthostatic Hypotension, Myocardial Infarction, And Syncope), Not For Use With Other Agents For Erectile Dysfunction, Predisposition To Prolonged Erection (as In Thrombocythemia, Polycythemia, Sickle Cell Anaemia, Multiple Myeloma Or Leukaemia). Urethral Application Is Contra-indicated In Balanitis, Severe Curvature, Severe Hypospadias, Urethral Stricture And Urethritis

Lactation

  • Consult with Doctor Or Caution Advised

Side Effects

  • Burning Sensation Or Tension In Penis During Erection
  • Penile Fibrosis
  • Erythema
  • Testicular Or Perineal Pain
  • Penile Deviations
  • Haemosiderin Deposits In Penis
  • Priapism
  • Changes In Blood Pressure
  • Cardiac Arrhythmias
  • Dizziness
  • Headache
  • Vagal Shock
  • Collapse
  • Peyronie's Disease
  • Muscle Spasm
  • And Peripheral Vascular Disorders. Urethral Application; Urethral Irritation

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