Azathioprine

Therapeutic Group

Immunosuppressants

Indication Dosage

Severe Acute Crohn's Disease, Maintenance Of Remission Of Crohn's Disease, Maintenance Of Remission Of Acute Ulcerative Colitis: 

  • Adult: 2-2.5 Mg/kg Daily, Some Patients May Respond To Lower Doses 

Rheumatoid Arthritis, Severe Systemic Lupus Erythematosus And Other Connective Tissue Disorders, Polymyositis: 

  • Adult: Initially Up To 2.5 Mg/kg Daily In Divided Doses, Adjusted According To Response, Rarely More Than 3 Mg/kg Daily; Maintenance 1-3 Mg/kg Daily, Discontinue If No Improvement Within 3 Months 

Autoimmune Conditions: 

  • Adult: 1-3 Mg/kg Daily, Adjusted According To Response, Discontinue If No Improvement Within3 Months 

Suppression Of Transplant Rejection: 

  • Adult: 1-2.5 Mg/kg Daily, Adjusted According To Response 

Severe Refractory Eczema: 

  • Adult: 1-3 Mg/kg Daily (with Normal Or High Tpmt Activity), 0.5-1.5 Mg/kg Daily (with Intermediate Tpmt Activity) 

Generalized Myasthenia Gravis: 

  • Adult: Initially 0.5-1 Mg/kg Daily, Then Increased To 2-2.5 Mg/kg Daily, Dose Is Increased Over 3-4 Weeks,

Content

  • Tab 50mg: Azathioprine 50mg.

Pregnancy

Consult with Doctor Or Caution Advised

Stability

  • Cytotoxic Immunosuppressant
  • Antimetabolites

Contra Indications

  • Biliary Stasis, Toxic Hepatitis, Absent Or Very Low Thiopurine Methyltransferase (tpmt) Activity

Precautions

  • Biliary Stasis, Toxic Hepatitis, Absent Or Very Low Thiopurine Methyltransferase (tpmt) Activity

Lactation

  • Consult with Doctor Or Caution Advised

Side Effects

  • Arthralgia
  • Cholestatic Jaundice
  • Diarrhoea
  • Dizziness
  • Dose-related Bone Marrow Suppression
  • Fever
  • Hair Loss
  • Herpes Zoster Infection
  • Hypersensitivity Reactions
  • Hypotension
  • Interstitial Nephritis
  • Liver Impairment
  • Malaise
  • Myalgia
  • Nausea
  • Neutropenia
  • Rash
  • Rigors
  • Thrombocytopenia
  • Vomiting.
  • Rare: Hepatic Veno-occlusive Disease
  • Lymphoma
  • Pancreatitis
  • Pneumonitis
  • Red Cell Aplasia