Bupivacaine

Therapeutic Group

Anaesthetic

Indication Dosage

Surgical Anaesthesia, Lumbar Epidural Block: 

By Regional Administration: 

  • Adult: 75-150 Mg, Dose Administered Using A 5 Mg/ml (0.5%) Solution 

Surgical Anaesthesia, Field Block: 

By Regional Administration: 

  • Adult: Up To 150 Mg, Dose Administered Using A 2.5 Mg/ml (0.25%) Or 5 Mg/ml (0.5%) Solution 

Surgical Anaesthesia, Thoracic Epidural Block: 

By Thoracic Epidural: 

  • Adult: 12.5-50 Mg, Dose Administered Using A 2.5 Mg/ml (0.25%) Or 5 Mg/ml (0.5%) Solution 
  • Children (up To 10 Yr): Using 0.25% Solution, Up To Lower Thoracic (t10) 0.3-0.4 Mu Kg, Up To Mid-thoracic (t6) 0.4-0.8 Ml/kg 

Surgical Anaesthesia, Caudal Epidural Block: 

By Regional Administration: 

  • Adult: 50-150 Mg, Dose Administered Using A 2.5 Mg/ml (0.25%) Or 5 Mg/ml (0.5%) Solution 

Surgical Anaesthesia, Major Nerve Block: 

By Regional Administration: 

  • Adult: 50-175 Mg, Dose Administered Using 5 Mg/ml (0.5%) Solution 

Acute Pain, Intra-articular Block: 

By Intra-Articular Inj: 

  • Adult: Up To 100 Mg, Dose Administered Using A 2.5 Mg/ml (0.25%) Solution; When Co-administered With Bupivacaine By Another Route, Total Max. 150mg 

Acute Pain, Thoracic Epidural Block: 

By Continuous Epidural Infusion: 

  • Adult: 6.3-18.8 Mg/hour, Dose Administered Using A 1.25 Mg/ml (0.125%) Or 2.5 Mg/ml (0.25%) Solution; Maximum 400 Mg Per Day 

Acute Pain, Labour: 

By Continuous Epidural Infusion: 

  • Adult: 6.25-12.5 Mg/hour, Dose Administered Using A 1.25 Mg/ml (0.125%) Solution; Maximum 400 Mg Per Day 

Acute Pain, Lumbar Epidural Block: 

By Lumbar Epidural: 

  • Adult: Initially 15-37.5 Mg, Then 15-37.5 Mg, Repeated When Required At Intervals Of At Least 30 Minutes, Dose Administered By Intermittent Injection Using A 2.5 Mg/ml (0.25%) Solution, Alternatively (by Continuous Epidural Infusion) 12.5-18.8 Mg/hour, Dose Administered Using A 1.25 Mg/ml (0.125%) Or 2.5 Mg/ml (0.25%) Solution; Maximum 400 Mg Per Day 

Acute Pain, Field Block: 

By Regional Administration: 

  • Adult: Up To 150 Mg, Dose Administered Using A 2.5 Mg/ml (0.25%) Solution

Content

  • Spinal Inj 0.75%: Per ml: Bupivacaine Hci 7.5mg (0.75%); 2 ml Amp
  • Inj 0.5%: Per ml: Bupivacaine 5mg (0.5%); 4 ml, 10 ml & 20 ml Amp.
  • Inj 0.25%: Per ml: Bupivacaine 2.5mg (0.25%); 20 ml Vial

Pregnancy

Consult with Doctor Or Caution Advised

Stability

  • Local Anaesthetic

Contra Indications

  • Application To The Middle Ear (can Cause Ototoxicity), Avoid Injection Into Infected Tissues Or Inflamed Tissues And Damaged Skin, Complete Heart Block. Children Below 12 Years Not Recommended,

Precautions

  • Application To The Middle Ear (can Cause Ototoxicity), Avoid Injection Into Infected Tissues Or Inflamed Tissues And Damaged Skin, Complete Heart Block. Children Below 12 Years Not Recommended,

Lactation

  • Consult with Doctor Or Caution Advised

Side Effects

  • Arrhythmias
  • Blurred Vision
  • Cardiac Arrest
  • Convulsions
  • Dizziness
  • Drowsiness
  • Feeling Of Inebriation
  • Headache
  • Lightheadedness
  • Muscle Twitching
  • Myocardial Depression (resulting In Hypotension And Bradycardia)
  • Nausea
  • Numbness Of The Tongue And Perioral Region
  • Paraesthesia (including Sensations Of Hot And Cold)
  • Peripheral Vasodilatation (resulting In Hypotension And Bradycardia)
  • Restlessness
  • Tinnitus
  • Transient Excitation (followed By Depression With Drowsiness
  • Respiratory Failure
  • Unconsciousness
  • And Coma)
  • Tremors
  • Vomiting

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