Cefotaxime

Therapeutic Group

Other Beta-Lactam, Cephalosporins & Penems

Indication Dosage

Infections Due To Sensitive Gram-positive And Gram-negative Bacteria, Surgical Prophylaxis, Haemophilus Epiglottitis: 

By IM Inj, OrIV Inj, Or Iv Infusion: 

  • Adult: 1 G Every 12 Hours 
  • Children: 100-150 Mg/kg Daily; Neonates, 50 Mg/kg Daily, In Two To Four Divided Doses; Max 200 Mg/kg Daily 

Severe Infections Due To Sensitive Gram-positive And Gram-negative Bacteria, Septicaemia, Meningitis: 

By IM Inj, OrIV Inj, Oriv Infusion: 

  • Adult: 8 G Daily In 4 Divided Doses, Increased If necessary To 12 G Daily In 3-4 Divided Doses. Im Doses Over 1 G Should Be Divided between More Than One Site 

By IV Inj: 

  • Children: 0-1 Week: 50 Mg/kg Every 12 Hr; 1-4 Weeks: 50 Mg/kg Every 8 Hr; 
  • 1 Month-12 Yr: Less Than 50 Kg Body Weight: 50-180 Mg/kg/day Divided Into 4-6 Doses. 

Emergency Treatment Of Suspected Bacterial Meningitis Or Meningococcal Disease, Before Urgent Transfer To Hospital: 

By Iv Or IM Inj: 

  • Adult & Children Above 12 Years: 1 G For 1 Dose 
  • Children 1 Month-11 Years: 50 Mg/kg For 1 Dose 

Uncomplicated Gonorrhoea 

By IM Inj: 

  • Adult: 500 Mg For 1 Dose 

Bone & Joints Infection: 

By IM Inj, Or IV Inj: 

  • Adults & Children: Above 50 Kg Body Weight: 1-2 Gm Every 8 Hr. Max: 12 Gm/day. 

By IV Inj: 

  • Children: 0-1 Week: 50 Mg/kg Every 12 Hr; 1-4 Weeks: 50 Mg/kg Every 8 Hr; 
  • 1 Month-12 Yr: Less Than 50 Kg Body Weight: 50-180 Mg/kg/day Divided Into 4-6 Doses.

Content

  • Inj 250mg /500mg /1gm /2gm: Cefotaxime Sodium Equiv To 250mg /500mg /1gm /2gmcefotaxime; Powder In Vial.

Pregnancy

No Evidence Of Harm

Stability

  • Antibacterials
  • Cephalosporins

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Caution Advised

Side Effects

  • Abdominal Discomfort
  • Agranulocytosis
  • allergic Reactions
  • anaphylaxis
  • Aplastic Anaemia
  • Blood Disorders
  • Confusion
  • Disturbances In Liver Enzymes
  • Dizziness
  • Eosinophilia
  • Haemolytic Anaemia
  • Headache
  • Hypertonia
  • Leucopenia
  • Nervousness
  • Pruritus
  • Rashes
  • Fever And Arthralgia
  • Sleep Disturbances
  • Urticaria
  • Gi Disturbances
  • Rare: Stevens-johnsonsyndrome
  • Thrombocytopenia
  • Toxic Epidermal Necrolysis
  • Transient Cholestatic Jaundice
  • Transient Hepatitis