Cefuroxime

Therapeutic Group

Other Beta-Lactam, Cephalosporins & Penems

Indication Dosage

Susceptible Infections Due To Gram-positive And Gram-negative Bacteria, Upper & Lower Respiratory Tract Infection: 

Oral: 

  • Adult: 250 Mg Twice Daily, Dose May Be Doubled In severe Lower Respiratory-tract Infections Or Ifpneumonia Is Suspected 
  • Children 3 Months - 1 Year: 10 Mg/kg Twice Daily (max. Per Dose 125 Mg); 2-11 Years: 15 Mg/kg Twice Daily (max. Per Dose 250 Mg); 
  • Child 12-17 Years: 250 Mg Twice Daily, Dose May Bedoubled In Severe Lower Respiratory-tract Infections Orif Pneumonia Is Suspected 

By IV Infusion, Or IV Inj, OrIM Inj: 

  • Adult: 750 Mg Every 6-8 Hours; Increased If Necessary up To 1.5 G Every 6-8 Hours, For Severe Infections And Cystic Fibrosis 
  • Children: 20 Mg/kg Every 8 Hours (max. Per Dose 750 Mg); Increased To 50-60 Mg/kg Every 6-8 Hours (max. Perdose 1.5 G), For Severe Infection and Cystic Fibrosis 

Septicaemia, Meningitis: 

By IV Inj :

  • Adults: 1.5 Gm Every 6 Hr. Max: 3 Gm Every 8 Hr. 
  • Children: 100-200 Mg/kg/day Divided Every 6-8 Hr; Max: 4.5 Gm/day Lyme Disease: 

Oral: 

  • Adult: 500 Mg Twice Daily For 14-21 Days (for 28 Days In Lyme Arthritis) 

Lower Urinary-tract Infection: 

Oral: 

  • Adult & Children Above 12 Years: 125 Mg Twice Daily 

Pyelonephritis, Pharyngitis, Tonsillitis: 

Oral: 

  • Adult: 250 Mg Twice Daily 
  • Children 3 Months-12 Yrs: 125 Mg Every 12 Hr For 10 Days Or 10 Mg/kg Every 12 Hr For 10 Days; Max: 500 Mg/day 

Sinusitis, Otitis Media: 

  • Children 3 Mth-12 Yr: 250 Mg Every 12 Hr For 10days Or 15 Mg/kg Every 12 Hr For 10 days; Max: 1 Gm/day 

Surgical Prophylaxis: 

By IV Inj: 

  • Adult: 1.5 G, To Be Administered Up To 30 Minutes Before The Procedure, Then (by IV Injection Or By IM Injection) 750 Mg Every 8 Hours If Required For Up To 3 Doses (in High-Risk Procedures) 

Bone Infection, Open Fractures, Prophylaxis: 

By IV Infusion, Or IV, Or IM Inj: 

  • Adult: 1.5 G Every 8 Hours Until Soft Tissue Closure (maximum Duration 72 Hours) 
  • Children 3 Months: 50 Mg/kg Every 8 Hr. Max: 4.5 Gm/day.

Content

  • Cap 250mg /500mg: Cefuroxime (as Cefuroxime Axetil) 250mg /500mg.
  • Tab 125mg /250mg /500mg: Cefuroxime (as Cefuroxime Axetil) 125mg /250mg /500mg.
  • Susp 125mg /250mg: Per 5 ml: Cefuroxime 125mg /250mg.

Pregnancy

Caution Advised

Stability

  • Cephalosporin Antibiotics

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Caution Advised, Avoid

Side Effects

  • Abdominal Discomfort
  • Agranulocytosis
  • Allergic Reactions
  • Anaphylaxis
  • Aplastic Anaemia
  • Blood Disorders
  • Confusion
  • Disturbances In Liver Enzymes
  • Dizziness
  • Eosinophilia
  • Haemolytic Anaemia
  • Hallucinations
  • Headache
  • Hypertonia
  • Leucopenia
  • Nervousness
  • Pruritus
  • Rashes
  • Fever And Arthralgia
  • Sleep Disturbances
  • Urticaria
  • Gi Disturbances
  • Rare: Stevens-johnson Syndrome
  • Thrombocytopenia
  • Toxic Epidermal Necrolysis
  • Transient Cholestatic Jaundice
  • Transient Hepatitis

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