Clopidogrel

Therapeutic Group

Anti-thrombotic Agents

Indication Dosage

Clopidogrel is a medication used to prevent blood clots in people with cardiovascular disease or those who have recently had a heart attack or stroke. It works by blocking platelets in the blood from sticking together, reducing the risk of clots forming. Clopidogrel is usually taken orally and can be taken with or without food. It is important to follow the dosage instructions given by your doctor to ensure the medication is effective and safe for you to take. Possible side effects include bleeding, stomach pain, and rash. If you experience any severe side effects or have any concerns, speak with your healthcare provider.

Prevention Of Atherothrombotic Events In Percutaneous Coronary Intervention (adjunct With Aspirin) In Patients Not Already On Clopidogrel: 

  • Adult: Loading Dose 300 Mg, To Be Taken Prior To The Procedure, Alternatively Loading Dose 600 Mg, Higher Dose May Produce A Greater And More Rapid Inhibition Of Platelet Aggregation 

Transient Or Acute Ischaemic Attack For Patients With Aspirin Hypersensitivity, Or Those Intolerant Of Aspirin Despite The Addition Of A Proton Pump Inhibitor: 

  • Adults: 75 Mg Daily 

Prevention Of Atherothrombotic Events In Acute Coronary Syndrome Without St-segment Elevation: 

  • Adults: 300 Mg Loading Dose Followed By 75 Mg Daily Given In Combination With 75-100 Mg Aspirin Daily, Up To 12 Months. 

Prevention Of Atherothrombotic Events In Acute Myocardial Infarction With St-segment Elevation: 

  • Adult 18-75 Years: Initially 300 Mg, Then 75 Mg For At Least 4 Weeks 
  • Adult 76 Years And Over: 75 Mg Daily For At Least 4 Weeks 

Prevention Of Atherothrombotic And Thromboembolic Events In Patients With Atrial Fibrillation And Risk Factor For A Vascular Event (with Aspirin) When Warfarin Is Unsuitable: 

  • Adult: 75 Mg Once Daily 
  • Children: Not Recommended.

Content

  • Tab 75mg /300mg: Clopidogrel (as Hydrogen Sula­phate) 75mgi300mg.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Antiplatelet

Contra Indications

  • Severe Hepatic Impairment, Active Bleeding Such As Peptic Ulcer Or Intracranial Haemorrhage.

Precautions

  • Severe Hepatic Impairment, Active Bleeding Such As Peptic Ulcer Or Intracranial Haemorrhage.

Lactation

  • Contraindicated or Not Recommended.

Side Effects

  • Headache
  • Bleeding Disorders; Including Gastro-intestinal And Intracranial
  • Diarrhoea
  • Dyspepsia
  • Constipation
  • Decreased Platelets
  • Dizziness
  • Duodenal Ulcers
  • Eosinophilia
  • Flatulence
  • Gastric Ulcer
  • Gastritis
  • Leucopenia
  • Nausea
  • Paraesthesia
  • Pruritus
  • Rash
  • Vomiting.
  • Rare: Vertigo
  • Thrombotic Thrombocytopenic Purpura.

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