Cyproterone Acetate

Therapeutic Group

Endocrine Hormone Therapy

Indication Dosage

Cyproterone acetate is a medication primarily indicated for the treatment of hyperandrogenism, hirsutism, and acne in individuals with conditions such as polycystic ovary syndrome (PCOS) and androgenetic alopecia. It is also utilized as a component of hormone replacement therapy for transgender women to suppress testosterone levels and promote feminization. 

Hyper-sexuality In Males, Sexual Deviation In Males: 

  • Adult: 50 Mg Twice Daily, To Be Taken After Food 

Prevention Of Tumour Flare With Initial Gonadorelin Analogue Therapy: 

  • Adult (Male): 200 Mg Daily In 2-3 Divided Doses For 5-7 Days Before Initiation Of Gonadorelin Analogue, Followed By 200 Mg Daily In 2-3 Divided Doses For 3-4 Weeks After Initiation Of Gonadorelin Analogue; Maximum 300 Mg Per Day. 

Long-term Palliative Therapy Where Gonadorelin Analogues Or Orchidectomy Contra-indicated, Not Tolerated, Or Where Oral Therapy Preferred: 

  • Adult (Male): 200-300 Mg Daily In 2-3 Divided Doses 

Hot Flushes With Gonadorelin Analogue Therapy Or After Orchidectomy: 

  • Adult (Male): Initially 50 Mg Daily, Then Adjusted According To Response To 50-150 Mg Daily In1-3 Divided Doses. 
  • Children: Not Applicable.

Content

  • Tab 10mg /50mg: Cyproterone Acetate10mg / 50mg.

Pregnancy

Consult with Doctor Or Caution Advised

Stability

  • Oral Anti-androgen

Contra Indications

  • Dubin-johnson Syndrome, History Of Thromboembolic Disorders, Liver-disease, Malignant Diseases, Previous Or Existing Liver Tumours, Rotor Syndrome, Severe Depression, Severe Diabetes (with Vascular Changes), Sickle-cell Anaemia, Wasting Diseases, Meningioma Or History Of Meningioma

Precautions

  • Dubin-johnson Syndrome, History Of Thromboembolic Disorders, Liver-disease, Malignant Diseases, Previous Or Existing Liver Tumours, Rotor Syndrome, Severe Depression, Severe Diabetes (with Vascular Changes), Sickle-cell Anaemia, Wasting Diseases, Meningioma Or History Of Meningioma

Lactation

  • Consult with Doctor Or Caution Advised

Side Effects

  • Breathlessness
  • Changes In Hair Pattern
  • Fatigue
  • Gynaecomastia (rarely Leading To Galactorrhoea And Benign Breast Nodules)
  • hepatic Failure
  • Hepatitis
  • Hepatotoxicity
  • Inhibition Of Spermatogenesis
  • Jaundice
  • Lassitude
  • Risk Of Recurrence Of Thromboembolic Disease.
  • Rare: Hypersensitivity Reactions
  • Osteoporosis
  • Rash

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