Doxycycline

Therapeutic Group

Tetracyclines

Indication Dosage

Upper Respiratory Infection & Lower Respiratory Infection: 

  • Adults: 100 Mg Every 12 hours on Day 1 Then 100 Mg Once Daily Or 50 Mg Every 12 Hr. In Severe Cases: 100 Mg Every 12 Hr. 
  • Children 8 Yrs (less Than 100 Lbs Body Weight): 1 Mg/lb Every 12 hours on Day 1, Then 1 Mg/lb Once Daily Or 0.5 Mg/lb Every 12 Hr. In Severe Case: 2 Mg/lb; Above 100 Lbs Body Weight: Same As Adult Dose. 

Inhalation Anthrax (post-exposure): 

  • Adults: 100 Mg Every 12 Hr For 60 Days. 
  • Children 8 Yrs Less Than 100 Lbs Body Weight: 1 Mg/lb Every 12 Hr For 60 Days; Above 100 Lbs Body Weight: Same As Adult Dose. 

Urinary Tract Infection: 

  • Adults: 100 Mg Every 12 Hr On Day 1, Then 100 Mg Once Daily Or 50 Mg Every 12 Hr. In Severe Infection; 200 Mg Once Daily 
  • Children 8 Yrs Less Than 100 Lbs Body Weight: 1 Mg/lb Every 12 Hr On Day 1, Then 1 Mg/lb Once Daily Or 0.5 Mg/lb Every 12 Hr; Above 100 Lbs Body Weight: Same As Adult Dose. 

Skin And Soft Tissue Infection: 

  • Adults: 100 Mg Every 12 Hr Or 50 Mg Every 6 Hr On Day 1, Then 100 Mg Once Daily Or 50 Mg Every 12 Hr. In Severe Case: 100 Mg Every 12 Hr. 
  • Children 8 Yrs Less Than 100 Lbs Body Weight: 1 Mg/lb Every 12 Hr On Day 1, Then 1 Mg/lb Once Daily Or 0.5 Mg/lb Every 12 Hr. Severe: 2 Mg/lb; Above 100 Lbs Body Weight: Same As Adult Dose. 

Susceptible Infections (e.g. Chlamydia, Rickettsia, And Mycoplasma): 

  • Adult And Children Above 12 Yrs: Initially 200 Mg Daily For 1 Dose, Then Maintenance 100 Mg Once Daily 

Early Syphilis: 

  • Adult & Children Above 12 Yrs: 100 Mg Twice Daily For 14 Days 

Late Latent Syphilis: 

  • Adult & Children Above 12 Yrs: 100 Mg Twice Daily For 28 Days 

Neurosyphilis: 

  • Adult: 200 Mg Twice Daily For 28 Days 

Uncomplicated Genital Chlamydia, Non-gonococcal Urethritis 

  • Adult & Children Above 12 Yrs: 100 Mg Twice Daily For 7 Days 

Pelvic Inflammatory Disease: 

  • Adult & Children Above 12 Yrs: 100 Mg Twice Daily For 14 Days 

Adjunct To Quinine In Treatment Of Plasmodium falciparum Malaria 

  • Adult & Children Above 12 yrs: 200 Mg Daily For 7 Days

Content

  • Cap /Tab: Doxycycline (as Hyclate) 100mg.
  • Inj: Per ml: Doxycycline (as Hyclate) 20mg; In 5 ml 100mg.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Antibacterials, Tetracyclines

Contra Indications

  • Children Under 12 Years (deposition In Growing Bone And Teeth, By Binding To Calcium, Causes Staining And Occasionally Dental Hypoplasia)

Precautions

  • Children Under 12 Years (deposition In Growing Bone And Teeth, By Binding To Calcium, Causes Staining And Occasionally Dental Hypoplasia)

Lactation

  • Contraindicated, Avoid

Side Effects

  • Anaphylaxis
  • Angioedema
  • Blood Disorders
  • Exfoliative Dermatitis
  • Hepatotoxicity
  • Hypersensitivity Reactions
  • Pancreatitis
  • Pericarditis
  • Photosensitivity
  • Rash
  • Stevens-johnson Syndrome
  • Urticaria
  • Colitis
  • Benign Intracranial Hypertension
  • Bulging Fontanelles
  • Diarrhoea
  • Dysphagia
  • Headache
  • Nausea
  • Oesophageal Irritation
  • Visual Disturbances
  • Vomiting
  • Anorexia
  • Anxiety
  • Flushing
  • Fungal Super-infection (when Used For Periodontitis)
  • Tinnitus
  • Oesophageal Ulcers
  • Photosensitivity
  • Hepatic Dysfunction

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