Fluconazole

Therapeutic Group

Anti-mycotics Systemic Use

Indication Dosage

Candidalbalanitis, Vaginal Candidiasis: 

Oral: 

  • Adult & Children Above 16 Yrs: 150 Mg For 1 Dose 

Vulvovaginal Candidiasis (Recurrent): 

Oral: 

  • Adult: Initially 150 Mg Every 72 Hours For 3 Doses, Then 150 Mg Once Weekly For 6 Months 

Mucosal Candidiasis (Except Genital): 

Oral, Or By Intravenous Infusion: 

  • Children 1 Month-11 Yrs: 3-6 Mg/kg, Dose To Be Given On first Day, Then 3 Mg/kg Daily (max. Per Dose 100 Mg); 
  • Adult & Children Above 12 Yrs: 50 Mg (Oral) Daily, Increased To 100 Mg Daily For Unusually Difficult infections. Doses To Be Taken For 7-14 Days In Oropharyngeal Candidiasis (max. 14 Days Except In Severely Immunocompromised Patients); For 14-30 Days In Other Mucosal Infections (E.g. Oesophagitis, Candiduria, Non-invasive Bronchopulmonary Infections)

Tineapedis, Corporis, Cruris, Pityriasisversicolor, Dermal Candidiasis: 

Oral: 

  • Adult: 50 Mg Daily For 2-4 Weeks (for Up To 6 Weeks In Tineapedis); Max. Duration Of Treatment 6 Weeks Invasive 

Candidal Infections Including Candidaemia, Disseminated Candidiasis; And Cryptococcal Infections Including Meningitis: 

Oral Or By IV Infusion: 

  • Adult: 400 Mg, Dose To Be Given On First Day, Then 200-400 Mg Daily (max. Per Dose 800 Mg Once Daily).
  • Children: 6-12 Mg/kg Daily (max. Per Dose 800 Mg) Treatment Continued According To Response (at Least 8 Weeks For Crypto Coccal Meningitis); Maximum Dose For Use In Severe Infections 

Prevention Of Fungal Infections In Immunocompromised Patients: 

Oral Or By IV Infusion: 

  • Adult: 50-400 Mg Daily; 
  • Children: 3-12 Mg/kg Daily (max. Per Dose 400 Mg) Start Treatment Before Anticipated Onset Of neutropenia And Continue For 7 Days After Neutrophil count In the Desirable Range, Dose Given According to Toextent And Duration Of Neutropenia 

Prevention Of Relapse Of Cryptococcal Meningitis In HIV infected patients After Completion Of Primary Therapy: 

Oral Or By IV Infusion: 

  • Adult: 200 Mg Daily

Content

  • Cap /Tab 50mg /100mg /150mg /200mg: Fluconazole 50mg /100mg /150mg /200mg
  • Inj Per ml: Fluconazole 2mg; 50 ml, 100 ml Vial.
  • Susp: Per 5 ml: Fluconazole 50mg; After Reconstitution

Pregnancy

Contraindicated

Stability

  • Triazole Antifungal

Contra Indications

  • Acute Porphyrias

Precautions

  • Acute Porphyrias

Lactation

  • Contraindicated

Side Effects

  • Abdominal Discomfort
  • Diarrhoea
  • Flatulence
  • Headache
  • Nausea
  • Rash
  • Alopecia
  • Anaphylaxis
  • Angioedema (in Children)
  • Dizziness
  • Dyspepsia
  • Hepatic Disorders
  • Hyperlipidaemia
  • Pruritus
  • Seizures
  • Stevens-johnson Syndrome
  • Taste Disturbance
  • Toxic Epidermal Necrolysis
  • Vomiting
  • Hypokalaemia
  • Leucopenia
  • Thrombocytopenia

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