Fluorouracil

Therapeutic Group

Anti-neoplastics

Indication Dosage

Fluorouracil is a medication used to treat skin problems like warts, sunspots, and certain types of skin cancer. It works by stopping the growth of abnormal skin cells and can help clear up these skin conditions when applied as directed by a healthcare professional.

Treatment Of Solid Tumours Including Gi Tract Cancers And Breast Cancer, Incombination With Folinic Acid In Advanced Colorectalcancer 

By IV Inj, Iv Infusion, Or Intra-arterial Infusion: 

  • Adults: Initial: 12 Mg/ Kg/day (up To 800 Mg/day) For 4 Days, Then 6 Mg/kg On Days 6, 8, 10 & 12. Maintenance: Either Repeat Initial Dose Every 30 Day Or After Toxic Signs Subside, Give 10-15 Mg/kg/wk As A Single Dose (up To 1 Gm/wk).

Content

  • Inj 250mg /500mg: 250mg /500mg 5-fluorouracil As Its Sodium Salt In 5 ml /10 ml Water For Inj; Vial.

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Antimetabolite

Contra Indications

  • Depressed Bone Marrow Function, Throm-bocytopenia, Serious Infection, Major Surgery.

Precautions

  • Depressed Bone Marrow Function, Throm-bocytopenia, Serious Infection, Major Surgery.

Lactation

  • Contraindicated. Discontinue Breast-feeding.

Side Effects

  • Alopecia
  • Bone-marrow Suppression
  • Desquamative Hand-foot Syndrome (on Prolonged Infusion)
  • Extravasation
  • Hyperuricaemia
  • Mucositis
  • Myleosuppression
  • Nausea
  • Oral Mucositis
  • Thromboembolism
  • Tumourlysis Syndrome
  • Vomiting.
  • Rare: Cerebellar Syndrome

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