Gentamicin

Therapeutic Group

Aminoglycoside Anti-bacterials

Indication Dosage

Gram-positive Bacterial Endocarditis Or Hacekendocarditis (in Combination With Other Antibacterials): 

By IM Inj, Or By Slow IV Inj, Or By IV Infusion: 

  • Adult: 1 Mg/kg Every 12 Hours, IV Injection To Be Administered Over At Least 3 Minutes, Daily Dose May Be Further Divided Septicaemia, Meningitis And Other CNS infections, Respiratory Tract Infection, Biliary Tract Infection, Acute Pyelonephritis, Endocarditis, Bone Infection Pneumonia In Hospital Patients, Adjunct In Listerial 

Meningitis Prostatitis: 

By IM Inj, Or By Slow IV Inj, Or By IV Infusion: 

  • Adult: 3-5 Mg/kg Daily In 3 Divided Doses, Divided Doses To Be Given Every 8 Hours, IV Injection To Be Administered Over At Least 3 Minutes 
  • Children: 2-2.5 Mg/kg Every 8 Hr. 
  • Infants/neonates: 2.5 Mg/kg Every 8 Hr. 1 Week Or Less: 2.5 Mg/kg Every 12 Hr. 

By IV Infusion: 

  • Adult: Initially 5-7 Mg/kg, Subsequent Doses Adjusted According To Serum-gentamicin Concentration, To Be Given In A Once Daily Dose Regimen 

Surgical Prophylaxis: 

By Slow IV Inj: 

  • Adult: 1.5 Mg/kg, IV Injection To Be Administered Over At Least 3 Minutes, Administer Dose Up To 30 Minutes Before The Procedure, Dose May Be Repeated Every 8 Hours For High-risk Procedures; Up To3 Further Doses May Be Given 

Surgical Prophylaxis (including Joint Replacement Surgery): 

By IV Infusion: 

  • Adult: 5 Mg/kg For 1 Dose, Administer Dose Up To30 Minutes Before The Procedure

Content

  • Inj 10mg /20mg /40mg /80mg /160mg: Per Amp: Gentamicin (as Sulphate) 10mg(2 .ml Amp) /20mg(2 ml Amp) / 40mg(1 ml Amp) /80mg(2 ml Amp) /160mg(2 ml Amp).

Pregnancy

Avoid, Use Only When No Safer Alternative Available

Stability

  • Aminoglycoside Antibiotics

Contra Indications

  • Myasthenia Gravis (aminoglycosides May Impair Neuromuscular Transmission).

Precautions

  • Myasthenia Gravis (aminoglycosides May Impair Neuromuscular Transmission).

Lactation

  • Caution Advised, Avoid

Side Effects

  • Auditory Damage
  • Impaired Neuromuscular Transmission
  • Irreversible Ototoxicity
  • Nephrotoxicity
  • Signs Of Liver Dysfunct
  • Transient Myasthenic Syndrome In Patients With Normal Neuromuscular Function With Large Doses Given During Surgery
  • Vestibular Damage.
  • Rare: Antibiotic-associated Colitis
  • Electrolyte Disturbances
  • Hypocalcaemia
  • Hypokalaemia
  • Hypomagnesaemia On Prolonged Therapy
  • Nausea
  • Peripheral Neuropathy
  • Stomatitis
  • Vomiting
  • Blood Disorders
  • Cns Effects
  • Convulsions
  • Encephalopathy
  • Rash

Available Brands