Amikacin

Therapeutic Group

Aminoglycoside Anti-bacterials

Indication Dosage

Serious Gram-negative Infections Resistant To Gentamicin Including, Bone & Joint Infections, Lower Respiratory Tract Infections, Septicemia And Meningitis: 

By IM Inj, Or By Slow IV Inj, Or By IV Infusion: 

  • Adult: 15 Mg/kg Daily In 2 Divided Doses, Increased To22.5 Mg/kg Daily In 3 Divided Doses For Up To 10 Days, Higher Dose To Be Used In Severe Infections; Maximum1.5 G Per Day; Maximum 15 G Per Course 
  • Children: Neonates: Initially 10 Mg/kg Then 15 Mg/kg Daily In Two Divided Doses; Others Same As Adults. 

By IV Infusion: 

  • Adult: Initially 15 Mg/kg (max. Per Dose 1.5 G Once Daily), Dose To Be Adjusted According To Serum-amikacin Concentration; Maximum 15 G Per Course

Content

  • Inj 25mg /50mg /100mg / 250mg /500mg: Per Vial: Amikacin (as Sulphate) 25mg /50mg /100mg / 250mg /500mg.

Pregnancy

Contraindicated

Stability

  • Aminoglycoside Antibiotics

Contra Indications

  • Myasthenia Gravis.

Precautions

  • Myasthenia Gravis.

Lactation

  • Contraindicated

Side Effects

  • Auditory Damage
  • Impaired Neuromuscular Transmission
  • Irreversible Ototoxicity
  • Nephrotoxicity
  • Transient Myasthenic Syndrome In Patients With Normal Neuromuscular Function With Large Doses Given During Surgery
  • Vestibular Damage.
  • Rare: Antibiotic-associated Colitis
  • Electrolyte Disturbances
  • Hypocalcaemia
  • Hypokalaemia
  • Hypomagnesaemia On Prolonged Therapy
  • Nausea
  • Peripheral Neuropathy
  • Stomatitis
  • Vomiting
  • Blood Disorders
  • Cns Effects
  • Convulsions
  • Encephalopathy
  • Rash

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