Glycopyrrolate

Therapeutic Group

Other Nervous System Drugs

Indication Dosage

Glycopyrrolate is a medication primarily prescribed to manage excessive drooling or saliva production in individuals with certain medical conditions, such as cerebral palsy and Parkinson's disease. It is also used to alleviate symptoms associated with gastrointestinal disorders like irritable bowel syndrome and peptic ulcers, by reducing stomach acid secretion. 

Control Of Upper Airway Secretions: 

Intra-operative: 

By IV Inj: 

  • Adult: 0.1 Mg Repeated As Needed At 2-3 Mins Intervals. 
  • Children: Neonate: 10 Mcg/kg, Repeated If Necessary; 1 Month-18 Yr: 4-8 Mcg/kg, Max 200 Mcg, Repeated If Necessary. 

Excessive Secretions Of The Respiratory Tract Preoperative: 

By IM Or IV Inj: 

  • Adult: 4.4 Mcg/kg 30-60 Min Before Procedure 
  • Children: Neonate: 5 Mcg/kg; 1 Month-12 Yr: 4-8 Mcg/kg, Max 200 Mcg; 12-18 Yr: 200-400 Mcg Or 4-5 Mcg/kg, Max 400 Mcg. 

Reverse Neuromuscular Blockade: 

By IV Inj: 

  • Adult: 0.2 Mg For Each 1 Mg Of Neostigmine Or 5 Mg Of Pyridostigmine Administered Or 5-15 Mcg/kg Glycopyrrolate With 25-70 Mcg/kg Of Neostigmine Or 0.1-0.3 Mg/kg Of Pyridostigmine (agents Usually Administered Simultaneously, But Glycopyrrolate May Be Administered First If Bradycardia Is Present). 
  • Children: Neonate, 10 Mcg/kg; 1 Month-12 Yr: 10 Mcg/kg, Max 500 Mcg; 12-18 Yr: 200 Mcg Per 1 Mg Of Neostigmine, Or 10-15 Mcg/kg. 

Adjunct In Treatment Of Peptic Ulcer: 

By IM Or IV Inj: 

  • Adult: 0.1-0.2 Mg 3-4 Times A Day. 

Oral: 

  • Adult: 1-2 Mg 2-3 Times Daily.

Content

  • Inj: Per 1 ml Amp: Glycopyrrolate 0.2mg.
  • Tab: Glycopyrrolate 1mg.

Pregnancy

Caution Advised

Stability

  • Anticholinergic
  • Antimuscarinics

Contra Indications

  • Acute Haemorrhage, Ulcerative Colitis, Narrow-angle Glaucoma, Tachycardia, Obstructive Uropathy, Paralytic Ileus, Obstructive Disease Of Gi Tract, Myasthenia Gravis, Hypersensitivity To Glycopyrrolate Or Any Component Of The Formulation. Not Recommended In Children <12 Years Of Age For The Management Of Peptic Ulcer; Infants, Patients With Down Syndrome, And Children With Spastic Paralysis Or Brain Damage May Be Hypersensitive To Antimuscarinic Effects.

Precautions

  • Acute Haemorrhage, Ulcerative Colitis, Narrow-angle Glaucoma, Tachycardia, Obstructive Uropathy, Paralytic Ileus, Obstructive Disease Of Gi Tract, Myasthenia Gravis, Hypersensitivity To Glycopyrrolate Or Any Component Of The Formulation. Not Recommended In Children <12 Years Of Age For The Management Of Peptic Ulcer; Infants, Patients With Down Syndrome, And Children With Spastic Paralysis Or Brain Damage May Be Hypersensitive To Antimuscarinic Effects.

Lactation

  • Caution Advised

Side Effects

  • Nausea
  • Vomiting
  • Dry Skin
  • Constipation
  • Dry Throat
  • Dry Mouth
  • Irritation At Injection Site
  • Dry Nose
  • Diaphoresis

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