Goserelin

Therapeutic Group

Pituitary And Hypothalamic Hormones And Analogues

Indication Dosage

Locally Advanced Prostate Cancer As An Alternative To Surgical Castration, Adjuvant Treatment To Radiotherapy Or Radical Prostatectomy, Neoadjuvant Treatment Prior To Radiotherapy In Advanced 

Prostate Cancer, Metastatic Prostate Cancer, Advanced Breast Cancer, Oestrogen-receptor-positive Early Breast Cancer: 

By Sc Inj: 

  • Adult: 3.6 Mg Every 28 Days, To Be Administered Into The Anterior Abdominal Wall 

Endometriosis: 

By Sc Inj: 

  • Adult: 3.6 Mg Every To Be Administered Into The Anterior Abdominal Wall 28 Days Maximum Duration Of Treatment 6 Months (do Not Repeat) 

Endometrial Thinning Before Intra-uterine Surgery: 

By Sc Inj: 

  • Adult: 3.6 Mg To Be Administered Into The Anterior Abdominal Wall, Dose May Be Repeated After 28 Days If Uterus Is Large Or To Allow Flexible Surgical Timing 

Before Surgery In Women Who Have Anaemia Due To Uterine Fibroids: 

By Sc Inj: 

  • Adult: 3.6 Mg With Supplementary Iron, To Be Administered Into The Anterior Abdominal Wall, After Every 28 Days; Maximum Duration Of Treatment 3 Months

Content

  • Depot Inj: Goserelin (as Acetate) 3.6mg In A Bio-degradable Depot; Single-dose Syringe Applicator, Implant Plus Applicator.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Gonadotrophin Releasing Hormones Analogue

Contra Indications

  • Undiagnosed Vaginal Bleeding, Use Longer Than 6 Months In Endometriosis (do Not Repeat)

Precautions

  • Undiagnosed Vaginal Bleeding, Use Longer Than 6 Months In Endometriosis (do Not Repeat)

Lactation

  • Contraindicated, Avoid

Side Effects

  • Anaphylaxis
  • Arthralgia
  • Asthma
  • Breast Tenderness
  • Changes In Blood Pressure
  • Changes In Breast Size
  • Changes In Scalp And Body Hair
  • Decrease In Trabecular Bone Density
  • Depression
  • Dizziness
  • Dyspareunia
  • Gi Disturbances
  • Gynaecomastia
  • Headache
  • Heart Failure
  • Hot Flushes
  • Hypersensitivity Reactions
  • Menopausal-like Symptoms
  • Migraine
  • Mood Changes
  • Musculoskeletal Pain And Weakness
  • Myalgia
  • Myocardial Infarction
  • Oedema Of The Face And Extremities
  • Ovarian Cysts (withdraw)
  • Palpitation
  • Paraesthesia
  • Pruritus
  • Rash
  • Sexual Dysfunction
  • Sleep Disorders
  • Urticaria
  • Vaginal Bleeding
  • Vaginal Dryness
  • Visual Disturbances
  • Weight Change
  • Withdrawal Bleeding

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