Leuprorelin Acetate

Therapeutic Group

Pituitary And Hypothalamic Hormones And Analogues

Indication Dosage

Advanced Prostate Cancer As An Alternative To Surgical Castration, Adjuvant Treatment To Radiotherapy Or Radical Prostatectomy In Advanced Prostate Cancer, Metastatic Prostate Cancer: 

By Sc Inj: 

  • Adult: 11.25 Mg Every 3 Months Or; 

By Sc Or IM Inj: 

  • Adult: 3.75 Mg Every Month 

Endometriosis: 

By IM Inj: 

  • Adult: Initially 11.25 Mg For 1 Dose As A Single Dose In the First 5 Days Of the Menstrual Cycle, Then 11.25 Mg Every 3 Months For a Maximum of 6 Months(course Not To Be Repeated) Or; 

By Sc Or IM Inj: 

  • Adult: Initially 3.75 Mg For 1 Dose As A Single Dose In the First 5 Days Of the Menstrual Cycle, Then 3.75 Mg Every Month For a Maximum of 6 Months (course Not To Be Repeated) 

Endometrial Thinning Before Intra-uterine Surgery: 

By Sc Or IM Inj: 

  • Adult: Initially 3.75 Mg For 1 Dose As A Single Dose Between Days 3 And 5 Of the Menstrual Cycle,5-6 Weeks Before Surgery 

Reduction Of Size Of Uterine Fibroids And Of Associated Bleeding Before Surgery: 

By Sc Or IM Inj: 

  • Adult: Initially 3.75 Mg Every Month Usually For 3-4 Months (maximum 6 Months)

Content

  • Inj 3.75mg /5mg /7.5mg /11.25mg /22.5mg: Le-uprorelin Acetate 3.75mg /5mg /7.5mg /11.25mg /22.5mg; Powder In Microcapsule Depot In Vial Plus 1 ml Diluent.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Gonadotrophin Releasing Hormones Analogue

Contra Indications

  • Undiagnosed Vaginal Bleeding.

Precautions

  • Undiagnosed Vaginal Bleeding.

Lactation

  • Contraindicated, Avoid

Side Effects

  • Altered Glucose Tolerance And Blood Lipids
  • Anaphylaxis
  • Anorexia
  • Asthma
  • Breast Tenderness (males And Females)
  • Changes In Blood Pressure
  • Breast Size And Scalp And Body Hair
  • Chills
  • Decrease In Trabecular Bone Density
  • Depression
  • Diarrhoea
  • Dizziness
  • Dyspareunia
  • Fatigue
  • Fever
  • Gi Disturbances
  • Headache
  • Hot Flushes
  • Hypersensitivity Reactions
  • Jaundice
  • Leucopenia
  • Local Reactions At Injection Site
  • Loss Of Libido
  • Menopausal-like Symptoms
  • Migraine
  • Mood Changes
  • Musculoskeletal Pain And Weakness
  • Nausea
  • Palpitation
  • Paraesthesia
  • Paralysis
  • Pruritus
  • Pulmonary Embolism
  • Rash
  • Sexual Dysfunction
  • Sleep Disturbances
  • Spinal Fracture
  • Thrombocytopenia
  • Urticaria
  • Vaginal Bleeding
  • Vaginal Dryness
  • Visual Disturbances
  • Vomiting
  • Weight Changes