Imipenem With Cilastatin
Therapeutic Group
Other Beta-Lactam, Cephalosporins & PenemsIndication Dosage
Aerobic And Anaerobic Gram-positive And Gram-negative Infections, Hospital-acquired Septicaemia:
By IV Infusion:
- Adult: 500 Mg Every 6 Hours, Alternatively 1 G Every8 Hours
Infection Caused By Pseudomonas Or Other Less Sensitive Organisms, Empirical Treatment Of Infection In Febrile Patients With Neutropenia, Life-threatening Infection:
By IV Infusion:
- Adult: 1 G Every 6 Hours
Lower Respiratory Tract, Intra-abdominal, Genitor-urinary, Gynaecological, Bone And Joint, Skin And Soft Tissue Infections, Septicaemia, Prophylaxis Of Post-operative Infections:
By IV Infusion:
- Adults: 250 Mg-1 Gm 6-8 Hourly, Depending On Type And Severity Of Infections. Prophylaxis: 1 Gm On Induction Of Anaesthesia Then 1 Gm Three hours later.
By Deep IM Inj:
- Adults: 500-750 Mg 12 Hourly Depending On Type And Severity Of Infection; Max 1.5 Gm Daily.
- Children Above 3 Months: 15 Mg/kg Body Weight Every 6 Hr. Max Daily Dose 2 Gm.
Gonococcal Urethritis Or Cervicitis:
By Deep IM Inj:
- Adults: 500 Mg As A Single Dose.
Content
- IV Inj 250mg /500mg: Imipenem (as Monohydrate), Cilastatin (as Sodium Salt) In Equal Parts; Powder In Vials.
Pregnancy
Avoid Unless Potential Benefit Outweighs Risk.
Stability
- Antibiotic, Carbapenem
Contra Indications
- None Known
Precautions
- None Known
Lactation
- Caution Advised, Avoid
Side Effects
- Diarrhoea
- Eosinophilia
- Nausea
- Rash
- Vomiting
- Confusion
- Dizziness
- Drowsiness
- Hallucinations
- Hypotension
- Leucopenia
- Myoclonicactivity
- Seizures
- Thrombocytopenia
- Thrombocytosis.
- Rare: Acute Renal Failure
- Anaphylactic Reactions
- Antibiotic-associated Colitis
- Encephalopathy
- Hearing Loss
- Hepatitis
- Paraesthesia
- Polyuria
- Stevens-johnson Syndrome
- Taste Disturbances
- Tooth
- Tongue Or Urine Discoloration
- Toxic Epidermal Necrolysis
- Tremor
- Neurotoxicity (at High Dose
- Renalfailure
- Cns Disease)