Infliximab
Therapeutic Group
ImmunosuppressantsIndication Dosage
Severe Active Crohn - s Disease, Fistulating Crohn - s Disease:
By IV Infusion:
- Adult: Initially 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Then 5 Mg/kg After 4 Weeks, Maintenance 5 Mg/kg Every 8 Weeks According To Response
Severe Active Ulcerative Colitis:
By IV Infusion:
- Adult: Initially 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Followed By 5 Mg/kg After 4 Weeks, Then 5 Mg/kg Every 8 Weeks, Discontinue If No Response
Rheumatoid Arthritis (in Combination With Methotrexate):
By IV Infusion:
- Adult: Initially 3 Mg/kg, Then 3 Mg/kg After 2 Weeks, Followed By 3 Mg/kg After 4 Weeks, Then 3 Mg/kg Every 8 Weeks, If Response Is Inadequate After 12 Weeks Of Initial Treatment; Increased In Steps Of 1.5 Mg/kg Every 8 Weeks, Up To 7.5 Mg/kg Every 8 Weeks, Discontinue If No Response By 12 Weeks Of Initial Infusion
Ankylosing Spondylitis:
By IV Infusion:
- Adult: 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Followed By 5 Mg/kg After 4 Weeks, Then 5 Mg/kg Every 6 - 8 Weeks, Discontinue If No Response By 6 Weeks Of Initial Infusion
Psoriatic Arthritis (in Combination With Methotrexate), Plaque Psoriasis:
By IV Infusion:
- Adult: 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Followed By 5 Mg/kg After 4 Weeks, Followed By 5 Mg/kg Every 8 Weeks
Content
- IV Inf 100mg: Infliximab 100mg In Vial
Pregnancy
Use Only If Essential
Stability
- Immunosuppressants, Tumor Necrosis Factor Alpha (tnf-a) Inhibitors
Contra Indications
- Moderate Or Severe Heart Failure, Severe Infections
Precautions
- Moderate Or Severe Heart Failure, Severe Infections
Lactation
- Caution Advised
Side Effects
- Alopecia
- Headache
- Development Of Antinuclear Antibodies
- Upper Respiratory Tract Infection
- Abdominal Pain
- Nausea
- Anaphylacticlike Reactions
- Development Of Antibodies To Double-stranded Dna
- Other Respiratory Infection
- Diarrhea
- Elevated Alanine Transaminase (alt)
- Bronchitis
- Dyspepsia
- Rash
- Fatigue
- Back Pain
- Rhinitis
- Urinary Tract Infection
- Arthralgia
- Fever
- Hypertension
- Pruritus
- Dyspnea
- Candidiasis
- Lupuslike Symptoms
- Lymphocytosis
- Neoplasms
- Nerve Disorders
- Pancreatitis
- Peripheral Ischaemia
- Pulmonary Oedema
- Seborrhea
- Seizure
- Syncope
- Thrombocytopenia
- Thrombophlebitis.
- Rare: Myocardial Ischemia Or Infarction
- Transient Visual Loss
- Heart Failure
- Agranulocytosis
- Serious Infections And Malignancies
- Circulatory Collapse
- Cyanosis
- Demyelinating Disorders
- Granuloma
- Haemolytic Anaemia
- Hepatitis B Reactivation
- Meningitis
- Pancytopenia
- Pericardial Effusion
- Sarcoidosis
- Severe Cutaneous Adverse Reactions (scars)
- Transverse Myelitis
- Vasculitis
- Vasospasm