Infliximab

Therapeutic Group

Immunosuppressants

Indication Dosage

Severe Active Crohn - s Disease, Fistulating Crohn - s Disease: 

By IV Infusion: 

  • Adult: Initially 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Then 5 Mg/kg After 4 Weeks, Maintenance 5 Mg/kg Every 8 Weeks According To Response 

Severe Active Ulcerative Colitis: 

By IV Infusion: 

  • Adult: Initially 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Followed By 5 Mg/kg After 4 Weeks, Then 5 Mg/kg Every 8 Weeks, Discontinue If No Response 

Rheumatoid Arthritis (in Combination With Methotrexate): 

By IV Infusion: 

  • Adult: Initially 3 Mg/kg, Then 3 Mg/kg After 2 Weeks, Followed By 3 Mg/kg After 4 Weeks, Then 3 Mg/kg Every 8 Weeks, If Response Is Inadequate After 12 Weeks Of Initial Treatment; Increased In Steps Of 1.5 Mg/kg Every 8 Weeks, Up To 7.5 Mg/kg Every 8 Weeks, Discontinue If No Response By 12 Weeks Of Initial Infusion 

Ankylosing Spondylitis: 

By IV Infusion: 

  • Adult: 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Followed By 5 Mg/kg After 4 Weeks, Then 5 Mg/kg Every 6 - 8 Weeks, Discontinue If No Response By 6 Weeks Of Initial Infusion 

Psoriatic Arthritis (in Combination With Methotrexate), Plaque Psoriasis: 

By IV Infusion: 

  • Adult: 5 Mg/kg, Then 5 Mg/kg After 2 Weeks, Followed By 5 Mg/kg After 4 Weeks, Followed By 5 Mg/kg Every 8 Weeks

Content

  • IV Inf 100mg: Infliximab 100mg In Vial

Pregnancy

Use Only If Essential

Stability

  • Immunosuppressants, Tumor Necrosis Factor Alpha (tnf-a) Inhibitors

Contra Indications

  • Moderate Or Severe Heart Failure, Severe Infections

Precautions

  • Moderate Or Severe Heart Failure, Severe Infections

Lactation

  • Caution Advised

Side Effects

  • Alopecia
  • Headache
  • Development Of Antinuclear Antibodies
  • Upper Respiratory Tract Infection
  • Abdominal Pain
  • Nausea
  • Anaphylacticlike Reactions
  • Development Of Antibodies To Double-stranded Dna
  • Other Respiratory Infection
  • Diarrhea
  • Elevated Alanine Transaminase (alt)
  • Bronchitis
  • Dyspepsia
  • Rash
  • Fatigue
  • Back Pain
  • Rhinitis
  • Urinary Tract Infection
  • Arthralgia
  • Fever
  • Hypertension
  • Pruritus
  • Dyspnea
  • Candidiasis
  • Lupuslike Symptoms
  • Lymphocytosis
  • Neoplasms
  • Nerve Disorders
  • Pancreatitis
  • Peripheral Ischaemia
  • Pulmonary Oedema
  • Seborrhea
  • Seizure
  • Syncope
  • Thrombocytopenia
  • Thrombophlebitis.
  • Rare: Myocardial Ischemia Or Infarction
  • Transient Visual Loss
  • Heart Failure
  • Agranulocytosis
  • Serious Infections And Malignancies
  • Circulatory Collapse
  • Cyanosis
  • Demyelinating Disorders
  • Granuloma
  • Haemolytic Anaemia
  • Hepatitis B Reactivation
  • Meningitis
  • Pancytopenia
  • Pericardial Effusion
  • Sarcoidosis
  • Severe Cutaneous Adverse Reactions (scars)
  • Transverse Myelitis
  • Vasculitis
  • Vasospasm

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